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Assay Detail

CHEMBL2401499

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Functional
Cytotoxicity against human SKHEP1 cells after 72 hrs by formazan test
13
Total Activities
11
Compounds Tested
2
Activity Types
0
Assay Parameters

Assay Information

Assay Type Functional
Organism Homo sapiens
Cell Type SK-HEP1
Confidence 1 — Organism
Curated By Autocuration

Target

SK-HEP1 (CHEMBL614912)
Type CELL-LINE
Organism Homo sapiens

Publication

Novel artemisinin derivatives with potential usefulness against liver/colon cancer and viral hepatitis.
Blazquez AG, Fernandez-Dolon M, Sanchez-Vicente L, Maestre AD, Gomez-San Miguel AB, Alvarez M, Serrano MA, Jansen H, Efferth T, Marin JJ, Romero MR.
Bioorg Med Chem (2013) 21 : 4432 -4441
PubMed 23685181 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 11 5.09 6.00
Activity 2 - -

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL2398389 1 6.00
CHEMBL2398387 1 5.70
CHEMBL2398386 1 5.40
CHEMBL2398390 1 5.05
CHEMBL2398388 1 5.00
CHEMBL361497 ARTESUNATE 4.0 2 5.00
CHEMBL2398392 1 4.60
CHEMBL520530 ANHYDRODIHYDROARTEMISININ 1 4.52
CHEMBL307261 ARTENIMOL 3.0 2 4.52
CHEMBL2398391 1 -
CHEMBL269671 ARTEMISININ 3.0 1 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL2398389 IC50 = 1000.0 nM 6.00
CHEMBL2398387 IC50 = 2000.0 nM 5.70
CHEMBL2398386 IC50 = 4000.0 nM 5.40
CHEMBL2398390 IC50 = 9000.0 nM 5.05
CHEMBL2398388 IC50 = 10000.0 nM 5.00
CHEMBL361497 ARTESUNATE IC50 = 10000.0 nM 5.00
CHEMBL2398392 IC50 = 25000.0 nM 4.60
CHEMBL520530 ANHYDRODIHYDROARTEMISININ IC50 = 30000.0 nM 4.52
CHEMBL307261 ARTENIMOL IC50 = 30000.0 nM 4.52
CHEMBL2398391 IC50 = 150000.0 nM -
CHEMBL269671 ARTEMISININ IC50 > 200000.0 nM -
CHEMBL307261 ARTENIMOL Activity - -
CHEMBL361497 ARTESUNATE Activity - -