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Assay Detail

CHEMBL2404074

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Functional
Antimalarial activity against chloroquine-resistant Plasmodium falciparum W2 after 72 hrs by MSF assay
26
Total Activities
22
Compounds Tested
2
Activity Types
0
Assay Parameters

Assay Information

Assay Type Functional
Organism Plasmodium falciparum
Confidence 1 — Organism
Curated By Autocuration

Target

Plasmodium falciparum (CHEMBL364)
Type ORGANISM
Organism Plasmodium falciparum

Publication

4-Amino-7-chloroquinolines: probing ligand efficiency provides botulinum neurotoxin serotype A light chain inhibitors with significant antiprotozoal activity.
Opsenica IM, Tot M, Gomba L, Nuss JE, Sciotti RJ, Bavari S, Burnett JC, Solaja BA.
J Med Chem (2013) 56 : 5860 -5871
PubMed 23815186 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 22 7.33 8.23
IC90 4 - -

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL2402910 2 8.23
CHEMBL1606 2 8.19
CHEMBL269671 ARTEMISININ 3.0 1 8.17
CHEMBL2402793 1 8.02
CHEMBL511003 2 7.96
CHEMBL2402789 1 7.84
CHEMBL2402784 1 7.72
CHEMBL42527 1 7.58
CHEMBL2402787 1 7.37
CHEMBL2402791 1 7.34
CHEMBL2402788 1 7.32
CHEMBL2402792 1 7.31
CHEMBL2402786 1 7.28
CHEMBL2402790 1 7.25
CHEMBL2402783 1 7.14
CHEMBL2402785 1 7.06
CHEMBL2402782 1 6.85
CHEMBL2402779 1 6.69
CHEMBL2402780 1 6.65
CHEMBL2402781 1 6.58
CHEMBL2402778 1 6.43
CHEMBL58510 CHLOROQUINE PHOSPHATE 4.0 2 6.20

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL2402910 IC50 = 5.93 nM 8.23
CHEMBL1606 IC50 = 6.5 nM 8.19
CHEMBL269671 ARTEMISININ IC50 = 6.7 nM 8.17
CHEMBL2402793 IC50 = 9.47 nM 8.02
CHEMBL511003 IC50 = 10.9 nM 7.96
CHEMBL2402789 IC50 = 14.33 nM 7.84
CHEMBL2402784 IC50 = 19.0 nM 7.72
CHEMBL42527 IC50 = 26.0 nM 7.58
CHEMBL2402787 IC50 = 42.4 nM 7.37
CHEMBL2402791 IC50 = 45.78 nM 7.34
CHEMBL2402788 IC50 = 48.44 nM 7.32
CHEMBL2402792 IC50 = 49.44 nM 7.31
CHEMBL2402786 IC50 = 52.17 nM 7.28
CHEMBL2402790 IC50 = 56.2 nM 7.25
CHEMBL2402783 IC50 = 72.97 nM 7.14
CHEMBL2402785 IC50 = 86.87 nM 7.06
CHEMBL2402782 IC50 = 140.81 nM 6.85
CHEMBL2402779 IC50 = 204.06 nM 6.69
CHEMBL2402780 IC50 = 225.38 nM 6.65
CHEMBL2402781 IC50 = 260.08 nM 6.58
CHEMBL2402778 IC50 = 375.05 nM 6.43
CHEMBL58510 CHLOROQUINE PHOSPHATE IC50 = 634.3 nM 6.20
CHEMBL1606 IC90 = 18.09 nM -
CHEMBL511003 IC90 = 14.11 nM -
CHEMBL2402910 IC90 = 7.41 nM -
CHEMBL58510 CHLOROQUINE PHOSPHATE IC90 = 942.5 nM -