Assay Detail
Binding
CHEMBL2404451
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Induction of polyamine transport system-mediated compound uptake in CHO cells after 48 hrs by MTS assay in presence of aminoguanidine
8
Total Activities
8
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Cricetulus griseus |
| Cell Type | CHO |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
Development of polyamine transport ligands with improved metabolic stability and selectivity against specific human cancers.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 8 | 7.10 | 7.66 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL541654 | — | — | 1 | 7.66 |
| CHEMBL557403 | — | — | 1 | 7.57 |
| CHEMBL558186 | — | — | 1 | 7.55 |
| CHEMBL2403109 | — | — | 1 | 7.52 |
| CHEMBL2403110 | — | — | 1 | 7.36 |
| CHEMBL2403111 | — | — | 1 | 7.08 |
| CHEMBL540552 | — | — | 1 | 6.50 |
| CHEMBL2403112 | — | — | 1 | 5.55 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL541654 | — | IC50 | = | 22.0 | nM | 7.66 |
| CHEMBL557403 | — | IC50 | = | 27.0 | nM | 7.57 |
| CHEMBL558186 | — | IC50 | = | 28.0 | nM | 7.55 |
| CHEMBL2403109 | — | IC50 | = | 30.0 | nM | 7.52 |
| CHEMBL2403110 | — | IC50 | = | 44.0 | nM | 7.36 |
| CHEMBL2403111 | — | IC50 | = | 83.0 | nM | 7.08 |
| CHEMBL540552 | — | IC50 | = | 320.0 | nM | 6.50 |
| CHEMBL2403112 | — | IC50 | = | 2800.0 | nM | 5.55 |