Assay Detail
Binding
CHEMBL2404710
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Inhibition of human recombinant CK2 expressed in Escherichia coli BL21(DE3) using RRRDDDSDDD as substrate after 15 mins by capillary electrophoretic analysis
19
Total Activities
19
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 5 — Multiple protein complex / RNA |
| Curated By | Autocuration |
Publication
Synthesis and biological evaluation of novel substituted pyrrolo[1,2-a]quinoxaline derivatives as inhibitors of the human protein kinase CK2.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 19 | 6.46 | 8.43 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1230165 | SILMITASERTIB | 2.0 | 1 | 8.43 |
| CHEMBL6246 | ELLAGIC ACID | 2.0 | 1 | 7.40 |
| CHEMBL2403133 | — | — | 1 | 7.31 |
| CHEMBL177820 | TETRABROMOBENZOTRIAZOLE | — | 1 | 7.22 |
| CHEMBL2403136 | — | — | 1 | 7.11 |
| CHEMBL2403135 | — | — | 1 | 6.93 |
| CHEMBL2403134 | — | — | 1 | 6.87 |
| CHEMBL289277 | EMODIN | — | 1 | 6.24 |
| CHEMBL2403137 | — | — | 1 | 6.08 |
| CHEMBL2403138 | — | — | 1 | 6.08 |
| CHEMBL2403127 | — | — | 1 | 6.07 |
| CHEMBL2403129 | — | — | 1 | 6.05 |
| CHEMBL2403126 | — | — | 1 | 6.01 |
| CHEMBL2403128 | — | — | 1 | 5.80 |
| CHEMBL2403132 | — | — | 1 | 5.72 |
| CHEMBL2403131 | — | — | 1 | 5.37 |
| CHEMBL2403130 | — | — | 1 | 5.08 |
| CHEMBL2403140 | — | — | 1 | - |
| CHEMBL2403139 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1230165 | SILMITASERTIB | IC50 | = | 3.7 | nM | 8.43 |
| CHEMBL6246 | ELLAGIC ACID | IC50 | = | 40.0 | nM | 7.40 |
| CHEMBL2403133 | — | IC50 | = | 49.0 | nM | 7.31 |
| CHEMBL177820 | TETRABROMOBENZOTRIAZOLE | IC50 | = | 60.0 | nM | 7.22 |
| CHEMBL2403136 | — | IC50 | = | 78.0 | nM | 7.11 |
| CHEMBL2403135 | — | IC50 | = | 118.0 | nM | 6.93 |
| CHEMBL2403134 | — | IC50 | = | 134.0 | nM | 6.87 |
| CHEMBL289277 | EMODIN | IC50 | = | 580.0 | nM | 6.24 |
| CHEMBL2403137 | — | IC50 | = | 834.0 | nM | 6.08 |
| CHEMBL2403138 | — | IC50 | = | 834.0 | nM | 6.08 |
| CHEMBL2403127 | — | IC50 | = | 850.0 | nM | 6.07 |
| CHEMBL2403129 | — | IC50 | = | 890.0 | nM | 6.05 |
| CHEMBL2403126 | — | IC50 | = | 982.0 | nM | 6.01 |
| CHEMBL2403128 | — | IC50 | = | 1570.0 | nM | 5.80 |
| CHEMBL2403132 | — | IC50 | = | 1890.0 | nM | 5.72 |
| CHEMBL2403131 | — | IC50 | = | 4280.0 | nM | 5.37 |
| CHEMBL2403130 | — | IC50 | = | 8250.0 | nM | 5.08 |
| CHEMBL2403140 | — | IC50 | - | — | - | |
| CHEMBL2403139 | — | IC50 | - | — | - |