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Assay Detail

CHEMBL2404829

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ADMET
Cytotoxicity against human HepG2 cells after 72 hrs by celltiter-glo assay
ChEMBL ↗
40
Total Activities
40
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type ADMET
Organism Homo sapiens
Cell Type HepG2
Confidence 1 — Organism
Curated By Autocuration

Target

HepG2 (CHEMBL395) ↗
Type CELL-LINE
Organism Homo sapiens

Publication

Evaluation of Jatropha isabelli natural products and their synthetic analogs as potential antimalarial therapeutic agents.
Hadi V, Hotard M, Ling T, Salinas YG, Palacios G, Connelly M, Rivas F.
Eur J Med Chem (2013) 65 : 376 -380
PubMed 23747806 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
EC50 40 4.60 5.21

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL2402276 JATROPHONE — 1 5.21
CHEMBL2402296 — — 1 4.73
CHEMBL2402306 — — 1 4.58
CHEMBL2402307 — — 1 4.58
CHEMBL2402308 — — 1 4.58
CHEMBL2402309 — — 1 4.58
CHEMBL2402310 — — 1 4.58
CHEMBL2401745 — — 1 4.58
CHEMBL2402311 — — 1 4.58
CHEMBL2402312 — — 1 4.58
CHEMBL2402304 — — 1 4.58
CHEMBL439422 ACETYL ALEURITOLIC ACID — 1 4.58
CHEMBL2402277 — — 1 4.58
CHEMBL2402278 — — 1 4.58
CHEMBL2402279 — — 1 4.58
CHEMBL2402280 — — 1 4.58
CHEMBL2402281 — — 1 4.58
CHEMBL2402282 — — 1 4.58
CHEMBL2402283 — — 1 4.58
CHEMBL2402284 — — 1 4.58
CHEMBL2402285 — — 1 4.58
CHEMBL2402286 — — 1 4.58
CHEMBL2402287 — — 1 4.58
CHEMBL2402288 — — 1 4.58
CHEMBL2402289 — — 1 4.58
CHEMBL2402290 — — 1 4.58
CHEMBL2402291 — — 1 4.58
CHEMBL2402292 — — 1 4.58
CHEMBL2402294 — — 1 4.58
CHEMBL2402293 — — 1 4.58

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL2402276 JATROPHONE EC50 = 6091.3 nM 5.21
CHEMBL2402296 — EC50 = 18737.6 nM 4.73
CHEMBL2402304 — EC50 = 26041.7 nM 4.58
CHEMBL2402295 — EC50 = 26041.7 nM 4.58
CHEMBL2402312 — EC50 = 26041.7 nM 4.58
CHEMBL2402311 — EC50 = 26041.7 nM 4.58
CHEMBL2401745 — EC50 = 26041.7 nM 4.58
CHEMBL2402310 — EC50 = 26041.7 nM 4.58
CHEMBL2402309 — EC50 = 26041.7 nM 4.58
CHEMBL2402308 — EC50 = 26041.7 nM 4.58
CHEMBL2402307 — EC50 = 26041.7 nM 4.58
CHEMBL2402306 — EC50 = 26041.7 nM 4.58
CHEMBL2402305 — EC50 = 26041.7 nM 4.58
CHEMBL2402275 — EC50 = 26041.7 nM 4.58
CHEMBL2402303 — EC50 = 26041.7 nM 4.58
CHEMBL2402302 — EC50 = 26041.7 nM 4.58
CHEMBL2402301 — EC50 = 26041.7 nM 4.58
CHEMBL2402300 — EC50 = 26041.7 nM 4.58
CHEMBL2402299 — EC50 = 26041.7 nM 4.58
CHEMBL2402298 — EC50 = 26041.7 nM 4.58
CHEMBL2402297 — EC50 = 26041.7 nM 4.58
CHEMBL2402285 — EC50 = 26041.7 nM 4.58
CHEMBL2402293 — EC50 = 26041.7 nM 4.58
CHEMBL2402294 — EC50 = 26041.7 nM 4.58
CHEMBL2402292 — EC50 = 26041.7 nM 4.58
CHEMBL2402291 — EC50 = 26041.7 nM 4.58
CHEMBL2402290 — EC50 = 26041.7 nM 4.58
CHEMBL2402289 — EC50 = 26041.7 nM 4.58
CHEMBL2402288 — EC50 = 26041.7 nM 4.58
CHEMBL2402287 — EC50 = 26041.7 nM 4.58
CHEMBL2402286 — EC50 = 26041.7 nM 4.58
CHEMBL439422 ACETYL ALEURITOLIC ACID EC50 = 26041.7 nM 4.58
CHEMBL2402284 — EC50 = 26041.7 nM 4.58
CHEMBL2402283 — EC50 = 26041.7 nM 4.58
CHEMBL2402282 — EC50 = 26041.7 nM 4.58
CHEMBL2402281 — EC50 = 26041.7 nM 4.58
CHEMBL2402280 — EC50 = 26041.7 nM 4.58
CHEMBL2402279 — EC50 = 26041.7 nM 4.58
CHEMBL2402278 — EC50 = 26041.7 nM 4.58
CHEMBL2402277 — EC50 = 26041.7 nM 4.58