Assay Detail
Binding
CHEMBL2404847
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of electric eel AChE using acetylthiocholine chloride as substrate preincubated for 15 mins followed by substrate addition measured every 1 min by Ellman's method
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Electrophorus electricus |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Design, synthesis, and evaluation of multitarget-directed resveratrol derivatives for the treatment of Alzheimer's disease.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 4 | 4.65 | 5.20 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL2402160 | — | — | 1 | 5.20 |
| CHEMBL2402067 | — | — | 1 | 4.44 |
| CHEMBL255231 | LADOSTIGIL | 2.0 | 1 | 4.30 |
| CHEMBL8706 | CLORGILINE | 2.0 | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL2402160 | — | IC50 | = | 6270.0 | nM | 5.20 |
| CHEMBL2402067 | — | IC50 | = | 36040.0 | nM | 4.44 |
| CHEMBL255231 | LADOSTIGIL | IC50 | = | 50000.0 | nM | 4.30 |
| CHEMBL8706 | CLORGILINE | IC50 | - | — | - |