Assay Detail
Functional
CHEMBL2405587
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Cytotoxicity against adriamycin-resistant human HepG2 cells assessed as growth inhibition after 48 hrs by MTT assay
7
Total Activities
7
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | HepG2 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Discovery of bufadienolides as a novel class of ClC-3 chloride channel activators with antitumor activities.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 7 | 5.86 | 6.46 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL399680 | BUFALIN | — | 1 | 6.46 |
| CHEMBL250785 | CINOBUFAGIN | — | 1 | 5.77 |
| CHEMBL2069023 | — | — | 1 | 5.62 |
| CHEMBL463065 | DESACETYLBUFOTALIN | — | 1 | 5.59 |
| CHEMBL2402164 | — | — | 1 | - |
| CHEMBL2069030 | — | — | 1 | - |
| CHEMBL2069056 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL399680 | BUFALIN | IC50 | = | 345.0 | nM | 6.46 |
| CHEMBL250785 | CINOBUFAGIN | IC50 | = | 1706.0 | nM | 5.77 |
| CHEMBL2069023 | — | IC50 | = | 2375.0 | nM | 5.62 |
| CHEMBL463065 | DESACETYLBUFOTALIN | IC50 | = | 2595.0 | nM | 5.59 |
| CHEMBL2402164 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL2069030 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL2069056 | — | IC50 | > | 100000.0 | nM | - |