Assay Detail
Binding
CHEMBL2405595
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Inhibition of human 11beta-HSD1 transfected in CHOP cells
11
Total Activities
11
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | CHOP |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
11-beta-hydroxysteroid dehydrogenase 1 (CHEMBL4235) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Mono-carbonyl curcumin analogues as 11β-hydroxysteroid dehydrogenase 1 inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 11 | 6.49 | 7.01 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1093862 | — | — | 1 | 7.01 |
| CHEMBL504452 | — | — | 1 | 6.94 |
| CHEMBL476847 | — | — | 1 | 6.84 |
| CHEMBL482409 | — | — | 1 | 6.71 |
| CHEMBL128729 | — | — | 1 | 6.59 |
| CHEMBL477256 | — | — | 1 | 6.58 |
| CHEMBL476846 | — | — | 1 | 6.51 |
| CHEMBL478480 | — | — | 1 | 6.46 |
| CHEMBL476220 | — | — | 1 | 6.29 |
| CHEMBL129134 | — | — | 1 | 6.08 |
| CHEMBL140 | CURCUMIN | 3.0 | 1 | 5.35 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1093862 | — | IC50 | = | 97.0 | nM | 7.01 |
| CHEMBL504452 | — | IC50 | = | 115.0 | nM | 6.94 |
| CHEMBL476847 | — | IC50 | = | 144.0 | nM | 6.84 |
| CHEMBL482409 | — | IC50 | = | 195.0 | nM | 6.71 |
| CHEMBL128729 | — | IC50 | = | 257.0 | nM | 6.59 |
| CHEMBL477256 | — | IC50 | = | 263.0 | nM | 6.58 |
| CHEMBL476846 | — | IC50 | = | 310.0 | nM | 6.51 |
| CHEMBL478480 | — | IC50 | = | 346.0 | nM | 6.46 |
| CHEMBL476220 | — | IC50 | = | 507.0 | nM | 6.29 |
| CHEMBL129134 | — | IC50 | = | 832.0 | nM | 6.08 |
| CHEMBL140 | CURCUMIN | IC50 | = | 4501.0 | nM | 5.35 |