Assay Detail

CHEMBL2405877

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Binding

Binding affinity to NTR3 (unknown origin)

ChEMBL ↗

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Target

Sortilin (CHEMBL3091) ↗

Open DB target context

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Primary target Sortilin

CHEMBL3091

Anchored from Assay target.

Protein identity Sortilin

Disease frame Disease evidence pending

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Review focus Open DB context pending

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Total Activities

Compounds Tested

Activity Types

Assay Parameters

Assay Information

Assay Type	Binding
Organism	Homo sapiens
Confidence	9 — Direct single protein target
Curated By	Autocuration

Target

Sortilin (CHEMBL3091) ↗

Type	SINGLE PROTEIN
Organism	Homo sapiens

Publication

The synthesis of neurotensin antagonist SR 48692 for prostate cancer research.

Baxendale IR, Cheung S, Kitching MO, Ley SV, Shearman JW.
Bioorg Med Chem (2013) 21 : 4378 -4387
PubMed 23721919 · DOI

Activity Statistics

Type	Count	Avg pChEMBL	Best pChEMBL
IC50	1	6.62	6.62

Compounds Tested

Compound	Name	Phase	Activities	Best pChEMBL
CHEMBL506981	REMINERTANT	3.0	1	6.62

Activity Data

Compound	Name	Type	Rel.	Value	Units	pChEMBL
CHEMBL506981	REMINERTANT	IC50	=	238.0	nM	6.62