Assay Detail
ADMET
CHEMBL2405901
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Cytotoxicity against african green monkey Vero cells assessed as growth inhibition after 72 hrs by MTS assay
14
Total Activities
14
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | ADMET |
| Organism | Chlorocebus sabaeus |
| Cell Type | Vero |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Synthesis of novel guttiferone A derivatives: in-vitro evaluation toward Plasmodium falciparum, Trypanosoma brucei and Leishmania donovani.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 14 | 4.86 | 6.48 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL267345 | AMPHOTERICIN B | 4.0 | 1 | 6.48 |
| CHEMBL2403407 | — | — | 1 | 5.42 |
| CHEMBL2403406 | — | — | 1 | 5.38 |
| CHEMBL452483 | GUTTIFERONE A | — | 1 | 5.15 |
| CHEMBL2403408 | — | — | 1 | 5.10 |
| CHEMBL2403392 | 14-O-METHYL-GUTTIFERONE A | — | 1 | 4.94 |
| CHEMBL2403394 | 14-O-METHOXYMETHYL-GUTTIFERONE A | — | 1 | 4.89 |
| CHEMBL76 | CHLOROQUINE | 4.0 | 1 | 4.68 |
| CHEMBL2403393 | — | — | 1 | 4.66 |
| CHEMBL2403401 | — | — | 1 | 4.49 |
| CHEMBL2403405 | — | — | 1 | 4.38 |
| CHEMBL55 | PENTAMIDINE | 4.0 | 1 | 4.24 |
| CHEMBL125 | MILTEFOSINE | 4.0 | 1 | 4.19 |
| CHEMBL2403409 | — | — | 1 | 4.00 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL267345 | AMPHOTERICIN B | IC50 | = | 330.0 | nM | 6.48 |
| CHEMBL2403407 | — | IC50 | = | 3770.0 | nM | 5.42 |
| CHEMBL2403406 | — | IC50 | = | 4120.0 | nM | 5.38 |
| CHEMBL452483 | GUTTIFERONE A | IC50 | = | 7050.0 | nM | 5.15 |
| CHEMBL2403408 | — | IC50 | = | 7900.0 | nM | 5.10 |
| CHEMBL2403392 | 14-O-METHYL-GUTTIFERONE A | IC50 | = | 11500.0 | nM | 4.94 |
| CHEMBL2403394 | 14-O-METHOXYMETHYL-GUTTIFERONE A | IC50 | = | 12950.0 | nM | 4.89 |
| CHEMBL76 | CHLOROQUINE | IC50 | = | 21000.0 | nM | 4.68 |
| CHEMBL2403393 | — | IC50 | = | 21750.0 | nM | 4.66 |
| CHEMBL2403401 | — | IC50 | = | 32650.0 | nM | 4.49 |
| CHEMBL2403405 | — | IC50 | = | 41650.0 | nM | 4.38 |
| CHEMBL55 | PENTAMIDINE | IC50 | = | 57000.0 | nM | 4.24 |
| CHEMBL125 | MILTEFOSINE | IC50 | = | 64960.0 | nM | 4.19 |
| CHEMBL2403409 | — | IC50 | = | 100000.0 | nM | 4.00 |