Assay Detail
Functional
CHEMBL2405902
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Leishmanicidal activity against promastigote stage of Leishmania donovani LV9 assessed as cell viability by MTT assay
23
Total Activities
23
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Leishmania donovani |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Synthesis of novel guttiferone A derivatives: in-vitro evaluation toward Plasmodium falciparum, Trypanosoma brucei and Leishmania donovani.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 23 | 4.95 | 7.52 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL267345 | AMPHOTERICIN B | 4.0 | 1 | 7.52 |
| CHEMBL2403406 | — | — | 1 | 5.30 |
| CHEMBL452483 | GUTTIFERONE A | — | 1 | 5.23 |
| CHEMBL2403392 | 14-O-METHYL-GUTTIFERONE A | — | 1 | 5.03 |
| CHEMBL2403393 | — | — | 1 | 4.91 |
| CHEMBL2403408 | — | — | 1 | 4.88 |
| CHEMBL2403394 | 14-O-METHOXYMETHYL-GUTTIFERONE A | — | 1 | 4.83 |
| CHEMBL2403398 | 14-O-ALLYL-GUTTIFERONE A | — | 1 | 4.80 |
| CHEMBL2403396 | 14-O-ETHYL-GUTTIFERONE A | — | 1 | 4.79 |
| CHEMBL125 | MILTEFOSINE | 4.0 | 1 | 4.79 |
| CHEMBL2401755 | 14-O-ISOPROPYL-GUTTIFERONE A | — | 1 | 4.74 |
| CHEMBL2403399 | 14-O-PROPARGYL-GUTTIFERONE A | — | 1 | 4.74 |
| CHEMBL2403397 | 14-O-PROPYL-GUTTIFERONE A | — | 1 | 4.68 |
| CHEMBL2403404 | 14-O-2-ETHYL-1,3-DIOXOLANE-GUTTIFERONE A | — | 1 | 4.65 |
| CHEMBL2403400 | 14-O-BENZYL-GUTTIFERONE A | — | 1 | 4.65 |
| CHEMBL2403395 | — | — | 1 | 4.63 |
| CHEMBL2403410 | — | — | 1 | 4.54 |
| CHEMBL2403405 | — | — | 1 | 4.46 |
| CHEMBL2403407 | — | — | 1 | - |
| CHEMBL2403401 | — | — | 1 | - |
| CHEMBL2403402 | 14-O-2-METHOXY-5-NITROBENZYL-GUTTIFERONE A | — | 1 | - |
| CHEMBL2403403 | — | — | 1 | - |
| CHEMBL2403409 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL267345 | AMPHOTERICIN B | IC50 | = | 30.0 | nM | 7.52 |
| CHEMBL2403406 | — | IC50 | = | 5040.0 | nM | 5.30 |
| CHEMBL452483 | GUTTIFERONE A | IC50 | = | 5830.0 | nM | 5.23 |
| CHEMBL2403392 | 14-O-METHYL-GUTTIFERONE A | IC50 | = | 9400.0 | nM | 5.03 |
| CHEMBL2403393 | — | IC50 | = | 12190.0 | nM | 4.91 |
| CHEMBL2403408 | — | IC50 | = | 13350.0 | nM | 4.88 |
| CHEMBL2403394 | 14-O-METHOXYMETHYL-GUTTIFERONE A | IC50 | = | 14630.0 | nM | 4.83 |
| CHEMBL2403398 | 14-O-ALLYL-GUTTIFERONE A | IC50 | = | 15690.0 | nM | 4.80 |
| CHEMBL2403396 | 14-O-ETHYL-GUTTIFERONE A | IC50 | = | 16180.0 | nM | 4.79 |
| CHEMBL125 | MILTEFOSINE | IC50 | = | 16240.0 | nM | 4.79 |
| CHEMBL2401755 | 14-O-ISOPROPYL-GUTTIFERONE A | IC50 | = | 18030.0 | nM | 4.74 |
| CHEMBL2403399 | 14-O-PROPARGYL-GUTTIFERONE A | IC50 | = | 18040.0 | nM | 4.74 |
| CHEMBL2403397 | 14-O-PROPYL-GUTTIFERONE A | IC50 | = | 20730.0 | nM | 4.68 |
| CHEMBL2403404 | 14-O-2-ETHYL-1,3-DIOXOLANE-GUTTIFERONE A | IC50 | = | 22200.0 | nM | 4.65 |
| CHEMBL2403400 | 14-O-BENZYL-GUTTIFERONE A | IC50 | = | 22360.0 | nM | 4.65 |
| CHEMBL2403395 | — | IC50 | = | 23280.0 | nM | 4.63 |
| CHEMBL2403410 | — | IC50 | = | 28950.0 | nM | 4.54 |
| CHEMBL2403405 | — | IC50 | = | 34340.0 | nM | 4.46 |
| CHEMBL2403407 | — | IC50 | - | — | - | |
| CHEMBL2403401 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL2403402 | 14-O-2-METHOXY-5-NITROBENZYL-GUTTIFERONE A | IC50 | > | 100000.0 | nM | - |
| CHEMBL2403403 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL2403409 | — | IC50 | > | 100000.0 | nM | - |