Assay Detail
Functional
CHEMBL2406003
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Cytotoxicity against human SJSA1 cells expressing wild type p53 assessed as growth inhibition by MTT assay
11
Total Activities
11
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | SJSA-1 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Discovery of RG7388, a potent and selective p53-MDM2 inhibitor in clinical development.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 11 | 6.91 | 8.00 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL2402737 | IDASANUTLIN | 3.0 | 1 | 8.00 |
| CHEMBL2402734 | — | — | 1 | 7.52 |
| CHEMBL2402733 | — | — | 1 | 7.40 |
| CHEMBL2402731 | — | — | 1 | 7.40 |
| CHEMBL2402735 | — | — | 1 | 7.30 |
| CHEMBL2402732 | — | — | 1 | 7.30 |
| CHEMBL2402736 | — | — | 1 | 7.05 |
| CHEMBL2402730 | — | — | 1 | 6.80 |
| CHEMBL2402729 | — | — | 1 | 5.88 |
| CHEMBL2402574 | — | — | 1 | 5.68 |
| CHEMBL2402573 | — | — | 1 | 5.68 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL2402737 | IDASANUTLIN | IC50 | = | 10.0 | nM | 8.00 |
| CHEMBL2402734 | — | IC50 | = | 30.0 | nM | 7.52 |
| CHEMBL2402733 | — | IC50 | = | 40.0 | nM | 7.40 |
| CHEMBL2402731 | — | IC50 | = | 40.0 | nM | 7.40 |
| CHEMBL2402735 | — | IC50 | = | 50.0 | nM | 7.30 |
| CHEMBL2402732 | — | IC50 | = | 50.0 | nM | 7.30 |
| CHEMBL2402736 | — | IC50 | = | 90.0 | nM | 7.05 |
| CHEMBL2402730 | — | IC50 | = | 160.0 | nM | 6.80 |
| CHEMBL2402729 | — | IC50 | = | 1320.0 | nM | 5.88 |
| CHEMBL2402574 | — | IC50 | = | 2100.0 | nM | 5.68 |
| CHEMBL2402573 | — | IC50 | = | 2100.0 | nM | 5.68 |