Assay Detail
Functional
CHEMBL2406201
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Antimalarial activity against multidrug-resistant Plasmodium falciparum TM90C2A after 72 hrs by MSF assay
8
Total Activities
4
Compounds Tested
2
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Plasmodium falciparum |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
4-Amino-7-chloroquinolines: probing ligand efficiency provides botulinum neurotoxin serotype A light chain inhibitors with significant antiprotozoal activity.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC90 | 4 | - | - |
| IC50 | 4 | 7.51 | 8.14 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL2402910 | — | — | 2 | 8.14 |
| CHEMBL511003 | — | — | 2 | 8.00 |
| CHEMBL1606 | — | — | 2 | 7.29 |
| CHEMBL58510 | CHLOROQUINE PHOSPHATE | 4.0 | 2 | 6.60 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL2402910 | — | IC50 | = | 7.16 | nM | 8.14 |
| CHEMBL511003 | — | IC50 | = | 9.94 | nM | 8.00 |
| CHEMBL1606 | — | IC50 | = | 51.12 | nM | 7.29 |
| CHEMBL58510 | CHLOROQUINE PHOSPHATE | IC50 | = | 249.84 | nM | 6.60 |
| CHEMBL1606 | — | IC90 | = | 132.73 | nM | - |
| CHEMBL58510 | CHLOROQUINE PHOSPHATE | IC90 | = | 510.46 | nM | - |
| CHEMBL2402910 | — | IC90 | = | 10.13 | nM | - |
| CHEMBL511003 | — | IC90 | = | 14.11 | nM | - |