Assay Detail
Functional
CHEMBL2406217
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Cytotoxicity against human HOS cells assessed as growth inhibition after 72 hrs by calcein AM staining-based fluoroscence assay
28
Total Activities
28
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | HOS |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
A novel series of highly potent 2,6,9-trisubstituted purine cyclin-dependent kinase inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 28 | 6.57 | 7.85 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL2402946 | — | — | 1 | 7.85 |
| CHEMBL2403095 | — | — | 1 | 7.62 |
| CHEMBL2403096 | — | — | 1 | 7.50 |
| CHEMBL2403094 | — | — | 1 | 7.36 |
| CHEMBL2403093 | — | — | 1 | 7.36 |
| CHEMBL2403097 | — | — | 1 | 7.05 |
| CHEMBL2403084 | — | — | 1 | 6.99 |
| CHEMBL2403088 | — | — | 1 | 6.99 |
| CHEMBL2403087 | — | — | 1 | 6.92 |
| CHEMBL2403092 | — | — | 1 | 6.91 |
| CHEMBL2403085 | — | — | 1 | 6.85 |
| CHEMBL2402954 | — | — | 1 | 6.82 |
| CHEMBL2402949 | — | — | 1 | 6.77 |
| CHEMBL2403098 | — | — | 1 | 6.75 |
| CHEMBL2403090 | — | — | 1 | 6.69 |
| CHEMBL2403083 | — | — | 1 | 6.68 |
| CHEMBL2403086 | — | — | 1 | 6.61 |
| CHEMBL2402952 | — | — | 1 | 6.54 |
| CHEMBL2403091 | — | — | 1 | 6.40 |
| CHEMBL2402947 | — | — | 1 | 6.31 |
| CHEMBL2403099 | — | — | 1 | 6.25 |
| CHEMBL2402951 | — | — | 1 | 6.03 |
| CHEMBL2402950 | — | — | 1 | 6.00 |
| CHEMBL2402945 | — | — | 1 | 5.94 |
| CHEMBL2402953 | — | — | 1 | 5.73 |
| CHEMBL2402948 | — | — | 1 | 5.69 |
| CHEMBL2403089 | — | — | 1 | 4.67 |
| CHEMBL14762 | SELICICLIB | 2.0 | 1 | 4.61 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL2402946 | — | IC50 | = | 14.0 | nM | 7.85 |
| CHEMBL2403095 | — | IC50 | = | 24.0 | nM | 7.62 |
| CHEMBL2403096 | — | IC50 | = | 32.0 | nM | 7.50 |
| CHEMBL2403094 | — | IC50 | = | 44.0 | nM | 7.36 |
| CHEMBL2403093 | — | IC50 | = | 44.0 | nM | 7.36 |
| CHEMBL2403097 | — | IC50 | = | 89.0 | nM | 7.05 |
| CHEMBL2403084 | — | IC50 | = | 102.0 | nM | 6.99 |
| CHEMBL2403088 | — | IC50 | = | 103.0 | nM | 6.99 |
| CHEMBL2403087 | — | IC50 | = | 120.0 | nM | 6.92 |
| CHEMBL2403092 | — | IC50 | = | 122.0 | nM | 6.91 |
| CHEMBL2403085 | — | IC50 | = | 140.0 | nM | 6.85 |
| CHEMBL2402954 | — | IC50 | = | 150.0 | nM | 6.82 |
| CHEMBL2402949 | — | IC50 | = | 170.0 | nM | 6.77 |
| CHEMBL2403098 | — | IC50 | = | 180.0 | nM | 6.75 |
| CHEMBL2403090 | — | IC50 | = | 206.0 | nM | 6.69 |
| CHEMBL2403083 | — | IC50 | = | 211.0 | nM | 6.68 |
| CHEMBL2403086 | — | IC50 | = | 247.0 | nM | 6.61 |
| CHEMBL2402952 | — | IC50 | = | 290.0 | nM | 6.54 |
| CHEMBL2403091 | — | IC50 | = | 398.0 | nM | 6.40 |
| CHEMBL2402947 | — | IC50 | = | 490.0 | nM | 6.31 |
| CHEMBL2403099 | — | IC50 | = | 560.0 | nM | 6.25 |
| CHEMBL2402951 | — | IC50 | = | 935.0 | nM | 6.03 |
| CHEMBL2402950 | — | IC50 | = | 995.0 | nM | 6.00 |
| CHEMBL2402945 | — | IC50 | = | 1160.0 | nM | 5.94 |
| CHEMBL2402953 | — | IC50 | = | 1881.0 | nM | 5.73 |
| CHEMBL2402948 | — | IC50 | = | 2030.0 | nM | 5.69 |
| CHEMBL2403089 | — | IC50 | = | 21410.0 | nM | 4.67 |
| CHEMBL14762 | SELICICLIB | IC50 | = | 24300.0 | nM | 4.61 |