Assay Detail
Functional
CHEMBL2406218
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Cytotoxicity against human G361 cells assessed as growth inhibition after 72 hrs by calcein AM staining-based fluoroscence assay
28
Total Activities
28
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | G-361 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
A novel series of highly potent 2,6,9-trisubstituted purine cyclin-dependent kinase inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 28 | 6.23 | 7.62 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL2402946 | — | — | 1 | 7.62 |
| CHEMBL2403093 | — | — | 1 | 7.31 |
| CHEMBL2403095 | — | — | 1 | 7.01 |
| CHEMBL2403094 | — | — | 1 | 7.01 |
| CHEMBL2403092 | — | — | 1 | 6.85 |
| CHEMBL2403096 | — | — | 1 | 6.82 |
| CHEMBL2403084 | — | — | 1 | 6.79 |
| CHEMBL2403088 | — | — | 1 | 6.66 |
| CHEMBL2403097 | — | — | 1 | 6.57 |
| CHEMBL2402947 | — | — | 1 | 6.41 |
| CHEMBL2403098 | — | — | 1 | 6.35 |
| CHEMBL2402949 | — | — | 1 | 6.30 |
| CHEMBL2402954 | — | — | 1 | 6.26 |
| CHEMBL2403087 | — | — | 1 | 6.24 |
| CHEMBL2402951 | — | — | 1 | 6.19 |
| CHEMBL2403086 | — | — | 1 | 6.18 |
| CHEMBL2403085 | — | — | 1 | 6.17 |
| CHEMBL2403091 | — | — | 1 | 6.14 |
| CHEMBL2403083 | — | — | 1 | 6.09 |
| CHEMBL2403090 | — | — | 1 | 6.05 |
| CHEMBL2402952 | — | — | 1 | 5.99 |
| CHEMBL2402950 | — | — | 1 | 5.83 |
| CHEMBL2402948 | — | — | 1 | 5.68 |
| CHEMBL2403099 | — | — | 1 | 5.68 |
| CHEMBL2402945 | — | — | 1 | 5.38 |
| CHEMBL2402953 | — | — | 1 | 5.38 |
| CHEMBL2403089 | — | — | 1 | 4.76 |
| CHEMBL14762 | SELICICLIB | 2.0 | 1 | 4.65 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL2402946 | — | IC50 | = | 24.0 | nM | 7.62 |
| CHEMBL2403093 | — | IC50 | = | 49.0 | nM | 7.31 |
| CHEMBL2403095 | — | IC50 | = | 97.0 | nM | 7.01 |
| CHEMBL2403094 | — | IC50 | = | 97.0 | nM | 7.01 |
| CHEMBL2403092 | — | IC50 | = | 140.0 | nM | 6.85 |
| CHEMBL2403096 | — | IC50 | = | 150.0 | nM | 6.82 |
| CHEMBL2403084 | — | IC50 | = | 164.0 | nM | 6.79 |
| CHEMBL2403088 | — | IC50 | = | 220.0 | nM | 6.66 |
| CHEMBL2403097 | — | IC50 | = | 272.0 | nM | 6.57 |
| CHEMBL2402947 | — | IC50 | = | 390.0 | nM | 6.41 |
| CHEMBL2403098 | — | IC50 | = | 443.0 | nM | 6.35 |
| CHEMBL2402949 | — | IC50 | = | 503.0 | nM | 6.30 |
| CHEMBL2402954 | — | IC50 | = | 545.0 | nM | 6.26 |
| CHEMBL2403087 | — | IC50 | = | 570.0 | nM | 6.24 |
| CHEMBL2402951 | — | IC50 | = | 640.0 | nM | 6.19 |
| CHEMBL2403086 | — | IC50 | = | 655.0 | nM | 6.18 |
| CHEMBL2403085 | — | IC50 | = | 670.0 | nM | 6.17 |
| CHEMBL2403091 | — | IC50 | = | 730.0 | nM | 6.14 |
| CHEMBL2403083 | — | IC50 | = | 815.0 | nM | 6.09 |
| CHEMBL2403090 | — | IC50 | = | 895.0 | nM | 6.05 |
| CHEMBL2402952 | — | IC50 | = | 1020.0 | nM | 5.99 |
| CHEMBL2402950 | — | IC50 | = | 1475.0 | nM | 5.83 |
| CHEMBL2402948 | — | IC50 | = | 2070.0 | nM | 5.68 |
| CHEMBL2403099 | — | IC50 | = | 2095.0 | nM | 5.68 |
| CHEMBL2402945 | — | IC50 | = | 4150.0 | nM | 5.38 |
| CHEMBL2402953 | — | IC50 | = | 4120.0 | nM | 5.38 |
| CHEMBL2403089 | — | IC50 | = | 17380.0 | nM | 4.76 |
| CHEMBL14762 | SELICICLIB | IC50 | = | 22400.0 | nM | 4.65 |