Assay Detail
Binding
CHEMBL2406225
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of human recombinant CDK2/Cyclin E expressed in baculovirus infected sf9 cells using histone H1 as substrate
27
Total Activities
27
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | Sf9 |
| Confidence | 7 — Homologous single protein target |
| Curated By | Autocuration |
Target
Cyclin-dependent kinase 2/cyclin E1 (CHEMBL1907605) ↗| Type | PROTEIN COMPLEX |
| Organism | Homo sapiens |
Publication
A novel series of highly potent 2,6,9-trisubstituted purine cyclin-dependent kinase inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 27 | 7.63 | 8.40 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL2403096 | — | — | 1 | 8.40 |
| CHEMBL2402946 | — | — | 1 | 8.15 |
| CHEMBL2402947 | — | — | 1 | 8.10 |
| CHEMBL2403095 | — | — | 1 | 8.10 |
| CHEMBL2403094 | — | — | 1 | 8.00 |
| CHEMBL2403091 | — | — | 1 | 8.00 |
| CHEMBL2403084 | — | — | 1 | 7.94 |
| CHEMBL2403088 | — | — | 1 | 7.92 |
| CHEMBL2403085 | — | — | 1 | 7.89 |
| CHEMBL2403093 | — | — | 1 | 7.85 |
| CHEMBL2403087 | — | — | 1 | 7.85 |
| CHEMBL2403097 | — | — | 1 | 7.75 |
| CHEMBL2402948 | — | — | 1 | 7.75 |
| CHEMBL2403086 | — | — | 1 | 7.70 |
| CHEMBL2402953 | — | — | 1 | 7.69 |
| CHEMBL2403098 | — | — | 1 | 7.64 |
| CHEMBL2402952 | — | — | 1 | 7.58 |
| CHEMBL2403090 | — | — | 1 | 7.51 |
| CHEMBL2402954 | — | — | 1 | 7.48 |
| CHEMBL2403092 | — | — | 1 | 7.47 |
| CHEMBL2403083 | — | — | 1 | 7.47 |
| CHEMBL2402949 | — | — | 1 | 7.39 |
| CHEMBL150261 | — | — | 1 | 7.32 |
| CHEMBL2402945 | — | — | 1 | 7.17 |
| CHEMBL2403099 | — | — | 1 | 6.92 |
| CHEMBL14762 | SELICICLIB | 2.0 | 1 | 6.77 |
| CHEMBL2403089 | — | — | 1 | 6.32 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL2403096 | — | IC50 | = | 4.0 | nM | 8.40 |
| CHEMBL2402946 | — | IC50 | = | 7.1 | nM | 8.15 |
| CHEMBL2402947 | — | IC50 | = | 8.0 | nM | 8.10 |
| CHEMBL2403095 | — | IC50 | = | 8.0 | nM | 8.10 |
| CHEMBL2403094 | — | IC50 | = | 10.0 | nM | 8.00 |
| CHEMBL2403091 | — | IC50 | = | 10.0 | nM | 8.00 |
| CHEMBL2403084 | — | IC50 | = | 11.4 | nM | 7.94 |
| CHEMBL2403088 | — | IC50 | = | 12.0 | nM | 7.92 |
| CHEMBL2403085 | — | IC50 | = | 13.0 | nM | 7.89 |
| CHEMBL2403093 | — | IC50 | = | 14.0 | nM | 7.85 |
| CHEMBL2403087 | — | IC50 | = | 14.0 | nM | 7.85 |
| CHEMBL2403097 | — | IC50 | = | 18.0 | nM | 7.75 |
| CHEMBL2402948 | — | IC50 | = | 18.0 | nM | 7.75 |
| CHEMBL2403086 | — | IC50 | = | 20.0 | nM | 7.70 |
| CHEMBL2402953 | — | IC50 | = | 20.5 | nM | 7.69 |
| CHEMBL2403098 | — | IC50 | = | 23.0 | nM | 7.64 |
| CHEMBL2402952 | — | IC50 | = | 26.0 | nM | 7.58 |
| CHEMBL2403090 | — | IC50 | = | 31.0 | nM | 7.51 |
| CHEMBL2402954 | — | IC50 | = | 33.0 | nM | 7.48 |
| CHEMBL2403092 | — | IC50 | = | 34.0 | nM | 7.47 |
| CHEMBL2403083 | — | IC50 | = | 33.5 | nM | 7.47 |
| CHEMBL2402949 | — | IC50 | = | 40.7 | nM | 7.39 |
| CHEMBL150261 | — | IC50 | = | 48.0 | nM | 7.32 |
| CHEMBL2402945 | — | IC50 | = | 68.0 | nM | 7.17 |
| CHEMBL2403099 | — | IC50 | = | 120.0 | nM | 6.92 |
| CHEMBL14762 | SELICICLIB | IC50 | = | 170.0 | nM | 6.77 |
| CHEMBL2403089 | — | IC50 | = | 478.0 | nM | 6.32 |