Assay Detail

CHEMBL2406433

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Binding

Inhibition of ALK (unknown origin)

ChEMBL ↗

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Target

ALK tyrosine kinase receptor (CHEMBL4247) ↗

Open DB target context

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Primary target ALK tyrosine kinase receptor

CHEMBL4247

Anchored from Assay target.

Protein identity ALK tyrosine kinase receptor

Disease frame Disease evidence pending

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Review focus Open DB context pending

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Total Activities

Compounds Tested

Activity Types

Assay Parameters

Assay Information

Assay Type	Binding
Organism	Homo sapiens
Confidence	9 — Direct single protein target
Curated By	Autocuration

Target

ALK tyrosine kinase receptor (CHEMBL4247) ↗

Type	SINGLE PROTEIN
Organism	Homo sapiens

Publication

LDK378: a promising anaplastic lymphoma kinase (ALK) inhibitor.

Chen J, Jiang C, Wang S.
J Med Chem (2013) 56 : 5673 -5674
PubMed 23837797 · DOI

Activity Statistics

Type	Count	Avg pChEMBL	Best pChEMBL
IC50	1	9.70	9.70

Compounds Tested

Compound	Name	Phase	Activities	Best pChEMBL
CHEMBL2403108	CERITINIB	4.0	1	9.70

Activity Data

Compound	Name	Type	Rel.	Value	Units	pChEMBL
CHEMBL2403108	CERITINIB	IC50	=	0.2	nM	9.70