Assay Detail
Functional
CHEMBL2406448
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Cytotoxicity against ERalpha and ERbeta-deficient human MDA-MB-231 cells assessed as growth inhibition after 72 hrs by MTT assay
11
Total Activities
11
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | MDA-MB-231 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Histone deacetylase inhibitors equipped with estrogen receptor modulation activity.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 11 | 4.81 | 5.47 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL98 | VORINOSTAT | 4.0 | 1 | 5.47 |
| CHEMBL2401849 | — | — | 1 | 5.09 |
| CHEMBL2401848 | — | — | 1 | 5.00 |
| CHEMBL2401846 | — | — | 1 | 4.85 |
| CHEMBL83 | TAMOXIFEN | 4.0 | 1 | 4.77 |
| CHEMBL2401845 | — | — | 1 | 4.65 |
| CHEMBL2401843 | — | — | 1 | 4.55 |
| CHEMBL691 | ETHINYL ESTRADIOL | 4.0 | 1 | 4.48 |
| CHEMBL2401847 | — | — | 1 | 4.47 |
| CHEMBL135 | ESTRADIOL | 4.0 | 1 | - |
| CHEMBL2401844 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL98 | VORINOSTAT | IC50 | = | 3400.0 | nM | 5.47 |
| CHEMBL2401849 | — | IC50 | = | 8100.0 | nM | 5.09 |
| CHEMBL2401848 | — | IC50 | = | 10000.0 | nM | 5.00 |
| CHEMBL2401846 | — | IC50 | = | 14100.0 | nM | 4.85 |
| CHEMBL83 | TAMOXIFEN | IC50 | = | 17000.0 | nM | 4.77 |
| CHEMBL2401845 | — | IC50 | = | 22600.0 | nM | 4.65 |
| CHEMBL2401843 | — | IC50 | = | 28400.0 | nM | 4.55 |
| CHEMBL691 | ETHINYL ESTRADIOL | IC50 | = | 32900.0 | nM | 4.48 |
| CHEMBL2401847 | — | IC50 | = | 33900.0 | nM | 4.47 |
| CHEMBL135 | ESTRADIOL | IC50 | - | — | - | |
| CHEMBL2401844 | — | IC50 | - | — | - |