Assay Detail
Binding
CHEMBL2406451
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Inhibition of human recombinant HDAC8 after 30 mins by fluorescence assay
8
Total Activities
8
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Histone deacetylase inhibitors equipped with estrogen receptor modulation activity.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 8 | 5.38 | 6.35 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL2401846 | — | — | 1 | 6.35 |
| CHEMBL98 | VORINOSTAT | 4.0 | 1 | 5.55 |
| CHEMBL2401845 | — | — | 1 | 5.40 |
| CHEMBL2401844 | — | — | 1 | 5.30 |
| CHEMBL2401843 | — | — | 1 | 4.96 |
| CHEMBL2401847 | — | — | 1 | 4.70 |
| CHEMBL2401849 | — | — | 1 | - |
| CHEMBL2401848 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL2401846 | — | IC50 | = | 450.0 | nM | 6.35 |
| CHEMBL98 | VORINOSTAT | IC50 | = | 2800.0 | nM | 5.55 |
| CHEMBL2401845 | — | IC50 | = | 4000.0 | nM | 5.40 |
| CHEMBL2401844 | — | IC50 | = | 5000.0 | nM | 5.30 |
| CHEMBL2401843 | — | IC50 | = | 11000.0 | nM | 4.96 |
| CHEMBL2401847 | — | IC50 | = | 20000.0 | nM | 4.70 |
| CHEMBL2401849 | — | IC50 | - | — | - | |
| CHEMBL2401848 | — | IC50 | - | — | - |