Assay Detail
Binding
CHEMBL2406591
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Inhibition of SARS coronavirus Chymotrypsin-like protease
10
Total Activities
9
Compounds Tested
2
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Severe acute respiratory syndrome-related coronavirus |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Replicase polyprotein 1a (CHEMBL3927) ↗| Type | SINGLE PROTEIN |
| Organism | Severe acute respiratory syndrome-related coronavirus |
Publication
Design, synthesis, and biological evaluation of novel dipeptide-type SARS-CoV 3CL protease inhibitors: structure-activity relationship study.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 5 | 6.53 | 8.12 |
| IC50 | 5 | 5.86 | 7.19 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL497141 | — | — | 1 | 8.12 |
| CHEMBL225515 | — | — | 1 | 7.19 |
| CHEMBL1929019 | — | — | 1 | 7.19 |
| CHEMBL2402691 | — | — | 1 | 6.22 |
| CHEMBL2402692 | — | — | 2 | 6.18 |
| CHEMBL539209 | — | — | 1 | 5.66 |
| CHEMBL2402694 | — | — | 1 | 5.50 |
| CHEMBL406516 | — | — | 1 | 5.00 |
| CHEMBL18786 | CINANSERIN | 2.0 | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL497141 | — | Ki | = | 7.5 | nM | 8.12 |
| CHEMBL225515 | — | Ki | = | 65.0 | nM | 7.19 |
| CHEMBL1929019 | — | IC50 | = | 65.0 | nM | 7.19 |
| CHEMBL2402691 | — | IC50 | = | 600.0 | nM | 6.22 |
| CHEMBL2402692 | — | Ki | = | 660.0 | nM | 6.18 |
| CHEMBL539209 | — | Ki | = | 2200.0 | nM | 5.66 |
| CHEMBL2402694 | — | Ki | = | 3200.0 | nM | 5.50 |
| CHEMBL2402692 | — | IC50 | = | 9100.0 | nM | 5.04 |
| CHEMBL406516 | — | IC50 | = | 10000.0 | nM | 5.00 |
| CHEMBL18786 | CINANSERIN | IC50 | = | 323000.0 | nM | - |