Assay Detail
Functional
CHEMBL2406592
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Cytotoxicity against human A549 cells after 48 hrs by MTT assay
52
Total Activities
52
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | A549 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Synthesis, anticancer activity and photophysical properties of novel substituted 2-oxo-2H-chromenylpyrazolecarboxylates.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 52 | 4.46 | 5.64 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL9514 | NOCODAZOLE | 2.0 | 1 | 5.64 |
| CHEMBL53463 | DOXORUBICIN | 4.0 | 1 | 5.40 |
| CHEMBL2402858 | — | — | 1 | 4.75 |
| CHEMBL101286 | — | — | 1 | 4.57 |
| CHEMBL2402865 | — | — | 1 | 4.55 |
| CHEMBL2402706 | — | — | 1 | 4.55 |
| CHEMBL2402860 | — | — | 1 | 4.52 |
| CHEMBL2401748 | — | — | 1 | 4.52 |
| CHEMBL2402727 | — | — | 1 | 4.47 |
| CHEMBL2402709 | — | — | 1 | 4.46 |
| CHEMBL2402712 | — | — | 1 | 4.46 |
| CHEMBL2402728 | — | — | 1 | 4.44 |
| CHEMBL2402859 | — | — | 1 | 4.42 |
| CHEMBL90142 | — | — | 1 | 4.37 |
| CHEMBL2402708 | — | — | 1 | 4.30 |
| CHEMBL2402867 | — | — | 1 | 4.29 |
| CHEMBL2402704 | — | — | 1 | 4.28 |
| CHEMBL2402866 | — | — | 1 | 4.28 |
| CHEMBL2402707 | — | — | 1 | 4.23 |
| CHEMBL2402705 | — | — | 1 | 4.07 |
| CHEMBL321131 | — | — | 1 | 4.07 |
| CHEMBL2402864 | — | — | 1 | 4.00 |
| CHEMBL2402710 | — | — | 1 | 4.00 |
| CHEMBL2402699 | — | — | 1 | - |
| CHEMBL2402698 | — | — | 1 | - |
| CHEMBL2402700 | — | — | 1 | - |
| CHEMBL2402703 | — | — | 1 | - |
| CHEMBL2402863 | — | — | 1 | - |
| CHEMBL2402862 | — | — | 1 | - |
| CHEMBL2402861 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL9514 | NOCODAZOLE | IC50 | = | 2310.0 | nM | 5.64 |
| CHEMBL53463 | DOXORUBICIN | IC50 | = | 4000.0 | nM | 5.40 |
| CHEMBL2402858 | — | IC50 | = | 18000.0 | nM | 4.75 |
| CHEMBL101286 | — | IC50 | = | 27000.0 | nM | 4.57 |
| CHEMBL2402865 | — | IC50 | = | 28000.0 | nM | 4.55 |
| CHEMBL2402706 | — | IC50 | = | 28000.0 | nM | 4.55 |
| CHEMBL2402860 | — | IC50 | = | 30000.0 | nM | 4.52 |
| CHEMBL2401748 | — | IC50 | = | 30000.0 | nM | 4.52 |
| CHEMBL2402727 | — | IC50 | = | 34000.0 | nM | 4.47 |
| CHEMBL2402712 | — | IC50 | = | 35000.0 | nM | 4.46 |
| CHEMBL2402709 | — | IC50 | = | 35000.0 | nM | 4.46 |
| CHEMBL2402728 | — | IC50 | = | 36000.0 | nM | 4.44 |
| CHEMBL2402859 | — | IC50 | = | 38000.0 | nM | 4.42 |
| CHEMBL90142 | — | IC50 | = | 43000.0 | nM | 4.37 |
| CHEMBL2402708 | — | IC50 | = | 50000.0 | nM | 4.30 |
| CHEMBL2402867 | — | IC50 | = | 51000.0 | nM | 4.29 |
| CHEMBL2402704 | — | IC50 | = | 52000.0 | nM | 4.28 |
| CHEMBL2402866 | — | IC50 | = | 52000.0 | nM | 4.28 |
| CHEMBL2402707 | — | IC50 | = | 59000.0 | nM | 4.23 |
| CHEMBL321131 | — | IC50 | = | 85000.0 | nM | 4.07 |
| CHEMBL2402705 | — | IC50 | = | 86000.0 | nM | 4.07 |
| CHEMBL2402864 | — | IC50 | = | 100000.0 | nM | 4.00 |
| CHEMBL2402710 | — | IC50 | = | 100000.0 | nM | 4.00 |
| CHEMBL412610 | — | IC50 | = | 119000.0 | nM | - |
| CHEMBL2402726 | — | IC50 | = | 146000.0 | nM | - |
| CHEMBL2402725 | — | IC50 | = | 175000.0 | nM | - |
| CHEMBL2402724 | — | IC50 | = | 189000.0 | nM | - |
| CHEMBL2402723 | — | IC50 | = | 165000.0 | nM | - |
| CHEMBL2402722 | — | IC50 | = | 179000.0 | nM | - |
| CHEMBL2402711 | — | IC50 | = | 165000.0 | nM | - |
| CHEMBL2402720 | — | IC50 | = | 163000.0 | nM | - |
| CHEMBL2402719 | — | IC50 | = | 178000.0 | nM | - |
| CHEMBL2402718 | — | IC50 | = | 136000.0 | nM | - |
| CHEMBL2402717 | — | IC50 | = | 221000.0 | nM | - |
| CHEMBL2402716 | — | IC50 | = | 171000.0 | nM | - |
| CHEMBL2402715 | — | IC50 | = | 132000.0 | nM | - |
| CHEMBL2402697 | — | IC50 | = | 150000.0 | nM | - |
| CHEMBL103836 | — | IC50 | = | 136000.0 | nM | - |
| CHEMBL2402695 | — | IC50 | = | 125000.0 | nM | - |
| CHEMBL2402721 | — | IC50 | = | 136000.0 | nM | - |
| CHEMBL2402696 | — | IC50 | = | 130000.0 | nM | - |
| CHEMBL2402702 | — | IC50 | = | 145000.0 | nM | - |
| CHEMBL2402701 | — | IC50 | = | 125000.0 | nM | - |
| CHEMBL2402861 | — | IC50 | = | 108000.0 | nM | - |
| CHEMBL2402862 | — | IC50 | = | 115000.0 | nM | - |
| CHEMBL2402863 | — | IC50 | = | 128000.0 | nM | - |
| CHEMBL2402703 | — | IC50 | = | 150000.0 | nM | - |
| CHEMBL2402700 | — | IC50 | = | 110000.0 | nM | - |
| CHEMBL2402698 | — | IC50 | = | 175000.0 | nM | - |
| CHEMBL2402699 | — | IC50 | = | 160000.0 | nM | - |