Assay Detail
Binding
CHEMBL2406602
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of human recombinant HDAC6 after 30 mins by fluorescence assay
8
Total Activities
8
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Histone deacetylase inhibitors equipped with estrogen receptor modulation activity.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 8 | 7.08 | 8.10 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL2401843 | — | — | 1 | 8.10 |
| CHEMBL2401846 | — | — | 1 | 7.89 |
| CHEMBL2401845 | — | — | 1 | 7.50 |
| CHEMBL98 | VORINOSTAT | 4.0 | 1 | 7.47 |
| CHEMBL2401844 | — | — | 1 | 6.85 |
| CHEMBL2401849 | — | — | 1 | 6.66 |
| CHEMBL2401848 | — | — | 1 | 6.25 |
| CHEMBL2401847 | — | — | 1 | 5.89 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL2401843 | — | IC50 | = | 8.0 | nM | 8.10 |
| CHEMBL2401846 | — | IC50 | = | 13.0 | nM | 7.89 |
| CHEMBL2401845 | — | IC50 | = | 32.0 | nM | 7.50 |
| CHEMBL98 | VORINOSTAT | IC50 | = | 34.0 | nM | 7.47 |
| CHEMBL2401844 | — | IC50 | = | 140.0 | nM | 6.85 |
| CHEMBL2401849 | — | IC50 | = | 221.0 | nM | 6.66 |
| CHEMBL2401848 | — | IC50 | = | 567.0 | nM | 6.25 |
| CHEMBL2401847 | — | IC50 | = | 1300.0 | nM | 5.89 |