Assay Detail
Functional
CHEMBL2406648
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Negative inotropic activity in guinea pig left atria assessed as decrease of 1 Hz current-induced developed tension
2
Total Activities
2
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Cavia porcellus |
| Tissue | Left cardiac atrium |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
Searching for new antiarrhythmic agents: evaluation of meta-hydroxymexiletine enantiomers.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 2 | 7.26 | 7.60 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL2401841 | — | — | 1 | 7.60 |
| CHEMBL2401842 | — | — | 1 | 6.92 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL2401841 | — | EC50 | = | 25.0 | nM | 7.60 |
| CHEMBL2401842 | — | EC50 | = | 120.0 | nM | 6.92 |