Assay Detail
Binding
CHEMBL2406828
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of ovine COX-2 assessed as using arachidonic acid as substrate preincubated for 5 mins prior to substrate addition measured after 2 hrs by enzyme immunoassay
9
Total Activities
9
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Ovis aries |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Stereoselective synthesis and anti-proliferative effects on prostate cancer evaluation of 5-substituted-3,4-diphenylfuran-2-ones.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 9 | 5.17 | 6.30 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL122 | ROFECOXIB | 4.0 | 1 | 6.30 |
| CHEMBL2403527 | — | — | 1 | 5.52 |
| CHEMBL2403543 | — | — | 1 | 5.15 |
| CHEMBL2403542 | — | — | 1 | 5.14 |
| CHEMBL51434 | — | — | 1 | 5.04 |
| CHEMBL2403603 | — | — | 1 | 4.92 |
| CHEMBL2403607 | — | — | 1 | 4.86 |
| CHEMBL2403544 | — | — | 1 | 4.84 |
| CHEMBL2403610 | — | — | 1 | 4.75 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL122 | ROFECOXIB | IC50 | = | 500.0 | nM | 6.30 |
| CHEMBL2403527 | — | IC50 | = | 3000.0 | nM | 5.52 |
| CHEMBL2403543 | — | IC50 | = | 7100.0 | nM | 5.15 |
| CHEMBL2403542 | — | IC50 | = | 7300.0 | nM | 5.14 |
| CHEMBL51434 | — | IC50 | = | 9200.0 | nM | 5.04 |
| CHEMBL2403603 | — | IC50 | = | 12100.0 | nM | 4.92 |
| CHEMBL2403607 | — | IC50 | = | 13900.0 | nM | 4.86 |
| CHEMBL2403544 | — | IC50 | = | 14600.0 | nM | 4.84 |
| CHEMBL2403610 | — | IC50 | = | 17600.0 | nM | 4.75 |