Assay Detail
Binding
CHEMBL2406859
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Inhibition of Trypanosoma brucei rhodesiense rhodesain
13
Total Activities
13
Compounds Tested
2
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Trypanosoma brucei rhodesiense |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Inhibition of rhodesain as a novel therapeutic modality for human African trypanosomiasis.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 7 | 7.84 | 8.70 |
| IC50 | 6 | 6.69 | 7.42 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL2402090 | — | — | 1 | 8.70 |
| CHEMBL2402091 | — | — | 1 | 8.10 |
| CHEMBL2402094 | — | — | 1 | 7.96 |
| CHEMBL2402095 | — | — | 1 | 7.44 |
| CHEMBL181752 | — | — | 1 | 7.42 |
| CHEMBL181504 | — | — | 1 | 7.22 |
| CHEMBL183767 | — | — | 1 | 7.10 |
| CHEMBL2402096 | — | — | 1 | 7.00 |
| CHEMBL92099 | — | — | 1 | 6.96 |
| CHEMBL181902 | — | — | 1 | 5.96 |
| CHEMBL367811 | — | — | 1 | 5.48 |
| CHEMBL2402093 | — | — | 1 | - |
| CHEMBL2402092 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL2402090 | — | Ki | = | 2.0 | nM | 8.70 |
| CHEMBL2402091 | — | Ki | = | 8.0 | nM | 8.10 |
| CHEMBL2402094 | — | Ki | = | 11.0 | nM | 7.96 |
| CHEMBL2402095 | — | Ki | = | 36.0 | nM | 7.44 |
| CHEMBL181752 | — | IC50 | = | 38.0 | nM | 7.42 |
| CHEMBL181504 | — | IC50 | = | 60.0 | nM | 7.22 |
| CHEMBL183767 | — | IC50 | = | 80.0 | nM | 7.10 |
| CHEMBL2402096 | — | Ki | = | 100.0 | nM | 7.00 |
| CHEMBL92099 | — | IC50 | = | 110.0 | nM | 6.96 |
| CHEMBL181902 | — | IC50 | = | 1100.0 | nM | 5.96 |
| CHEMBL367811 | — | IC50 | = | 3330.0 | nM | 5.48 |
| CHEMBL2402093 | — | Ki | - | — | - | |
| CHEMBL2402092 | — | Ki | - | — | - |