Assay Detail
Binding
CHEMBL2410095
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of recombinant C-terminal FLAG-tagged HDAC1 (unknown origin) expressed in Escherichia coli BL21 using MAL as substrate incubated for 1 hr prior to substrate addition measured after 60 mins by fluorescence plate reader analysis
19
Total Activities
19
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Discovery of potent, isoform-selective inhibitors of histone deacetylase containing chiral heterocyclic capping groups and a N-(2-aminophenyl)benzamide binding unit.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 19 | 6.44 | 7.01 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL272980 | MOCETINOSTAT | 2.0 | 1 | 7.01 |
| CHEMBL2407719 | — | — | 1 | 6.75 |
| CHEMBL2407733 | — | — | 1 | 6.72 |
| CHEMBL2407736 | — | — | 1 | 6.46 |
| CHEMBL2407718 | — | — | 1 | 6.43 |
| CHEMBL2407721 | — | — | 1 | 6.39 |
| CHEMBL2407731 | — | — | 1 | 6.30 |
| CHEMBL2407723 | — | — | 1 | 6.26 |
| CHEMBL2407720 | — | — | 1 | 6.04 |
| CHEMBL2407717 | — | — | 1 | 6.03 |
| CHEMBL2407716 | — | — | 1 | - |
| CHEMBL2407738 | — | — | 1 | - |
| CHEMBL2407737 | — | — | 1 | - |
| CHEMBL2407722 | — | — | 1 | - |
| CHEMBL2407735 | — | — | 1 | - |
| CHEMBL2407734 | — | — | 1 | - |
| CHEMBL2407724 | — | — | 1 | - |
| CHEMBL2407732 | — | — | 1 | - |
| CHEMBL2407725 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL272980 | MOCETINOSTAT | IC50 | = | 98.0 | nM | 7.01 |
| CHEMBL2407719 | — | IC50 | = | 180.0 | nM | 6.75 |
| CHEMBL2407733 | — | IC50 | = | 190.0 | nM | 6.72 |
| CHEMBL2407736 | — | IC50 | = | 350.0 | nM | 6.46 |
| CHEMBL2407718 | — | IC50 | = | 370.0 | nM | 6.43 |
| CHEMBL2407721 | — | IC50 | = | 410.0 | nM | 6.39 |
| CHEMBL2407731 | — | IC50 | = | 500.0 | nM | 6.30 |
| CHEMBL2407723 | — | IC50 | = | 550.0 | nM | 6.26 |
| CHEMBL2407720 | — | IC50 | = | 920.0 | nM | 6.04 |
| CHEMBL2407717 | — | IC50 | = | 930.0 | nM | 6.03 |
| CHEMBL2407716 | — | IC50 | - | — | - | |
| CHEMBL2407738 | — | IC50 | - | — | - | |
| CHEMBL2407737 | — | IC50 | - | — | - | |
| CHEMBL2407722 | — | IC50 | - | — | - | |
| CHEMBL2407735 | — | IC50 | - | — | - | |
| CHEMBL2407734 | — | IC50 | - | — | - | |
| CHEMBL2407724 | — | IC50 | - | — | - | |
| CHEMBL2407732 | — | IC50 | - | — | - | |
| CHEMBL2407725 | — | IC50 | - | — | - |