Assay Detail
Binding
CHEMBL2410352
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Displacement of [3H]Epibatidine from human alpha7 nACHR expressed in CHO cell membranes after 2 hrs by liquid scintillation counting analysis
36
Total Activities
36
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | CHO |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Neuronal acetylcholine receptor subunit alpha-7 (CHEMBL2492) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Novel nicotinic acetylcholine receptor agonists containing carbonyl moiety as a hydrogen bond acceptor.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 36 | 5.97 | 8.30 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL2409491 | — | — | 1 | 8.30 |
| CHEMBL2409487 | — | — | 1 | 8.00 |
| CHEMBL2179962 | — | — | 1 | 7.70 |
| CHEMBL2409489 | — | — | 1 | 7.52 |
| CHEMBL2409486 | — | — | 1 | 7.00 |
| CHEMBL2409492 | — | — | 1 | 7.00 |
| CHEMBL3037927 | — | — | 1 | 6.85 |
| CHEMBL2409490 | — | — | 1 | 6.52 |
| CHEMBL2409485 | — | — | 1 | 6.52 |
| CHEMBL2409482 | — | — | 1 | 6.46 |
| CHEMBL2409488 | — | — | 1 | 6.40 |
| CHEMBL2179961 | — | — | 1 | 6.08 |
| CHEMBL2409480 | — | — | 1 | 6.00 |
| CHEMBL2409478 | — | — | 1 | 5.85 |
| CHEMBL2409496 | — | — | 1 | 5.80 |
| CHEMBL2409483 | — | — | 1 | 5.72 |
| CHEMBL2409479 | — | — | 1 | 5.57 |
| CHEMBL3 | NICOTINE | 4.0 | 1 | 5.52 |
| CHEMBL2409495 | — | — | 1 | 5.48 |
| CHEMBL3037928 | — | — | 1 | 5.47 |
| CHEMBL2409494 | — | — | 1 | 5.40 |
| CHEMBL2409481 | — | — | 1 | 5.35 |
| CHEMBL2179529 | AZD1446 | 2.0 | 1 | 5.17 |
| CHEMBL2409477 | — | — | 1 | 5.16 |
| CHEMBL2409476 | — | — | 1 | 5.00 |
| CHEMBL2407115 | — | — | 1 | 4.96 |
| CHEMBL3037929 | — | — | 1 | 4.89 |
| CHEMBL2409473 | — | — | 1 | 4.82 |
| CHEMBL3037926 | — | — | 1 | 4.57 |
| CHEMBL2409484 | — | — | 1 | 4.00 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL2409491 | — | Ki | = | 5.0 | nM | 8.30 |
| CHEMBL2409487 | — | Ki | = | 10.0 | nM | 8.00 |
| CHEMBL2179962 | — | Ki | = | 20.0 | nM | 7.70 |
| CHEMBL2409489 | — | Ki | = | 30.0 | nM | 7.52 |
| CHEMBL2409486 | — | Ki | = | 100.0 | nM | 7.00 |
| CHEMBL2409492 | — | Ki | = | 100.0 | nM | 7.00 |
| CHEMBL3037927 | — | Ki | = | 140.0 | nM | 6.85 |
| CHEMBL2409490 | — | Ki | = | 300.0 | nM | 6.52 |
| CHEMBL2409485 | — | Ki | = | 300.0 | nM | 6.52 |
| CHEMBL2409482 | — | Ki | = | 350.0 | nM | 6.46 |
| CHEMBL2409488 | — | Ki | = | 400.0 | nM | 6.40 |
| CHEMBL2179961 | — | Ki | = | 840.0 | nM | 6.08 |
| CHEMBL2409480 | — | Ki | = | 990.0 | nM | 6.00 |
| CHEMBL2409478 | — | Ki | = | 1400.0 | nM | 5.85 |
| CHEMBL2409496 | — | Ki | = | 1600.0 | nM | 5.80 |
| CHEMBL2409483 | — | Ki | = | 1900.0 | nM | 5.72 |
| CHEMBL2409479 | — | Ki | = | 2700.0 | nM | 5.57 |
| CHEMBL3 | NICOTINE | Ki | = | 3000.0 | nM | 5.52 |
| CHEMBL2409495 | — | Ki | = | 3300.0 | nM | 5.48 |
| CHEMBL3037928 | — | Ki | = | 3400.0 | nM | 5.47 |
| CHEMBL2409494 | — | Ki | = | 4000.0 | nM | 5.40 |
| CHEMBL2409481 | — | Ki | = | 4500.0 | nM | 5.35 |
| CHEMBL2179529 | AZD1446 | Ki | = | 6700.0 | nM | 5.17 |
| CHEMBL2409477 | — | Ki | = | 6900.0 | nM | 5.16 |
| CHEMBL2409476 | — | Ki | = | 10000.0 | nM | 5.00 |
| CHEMBL2407115 | — | Ki | = | 11000.0 | nM | 4.96 |
| CHEMBL3037929 | — | Ki | = | 13000.0 | nM | 4.89 |
| CHEMBL2409473 | — | Ki | = | 15000.0 | nM | 4.82 |
| CHEMBL3037926 | — | Ki | = | 27000.0 | nM | 4.57 |
| CHEMBL2409484 | — | Ki | = | 100000.0 | nM | 4.00 |
| CHEMBL2409493 | — | Ki | - | — | - | |
| CHEMBL2409497 | — | Ki | - | — | - | |
| CHEMBL2409498 | — | Ki | - | — | - | |
| CHEMBL2409472 | — | Ki | - | — | - | |
| CHEMBL2409474 | — | Ki | - | — | - | |
| CHEMBL2409475 | — | Ki | - | — | - |