Assay Detail
Binding
CHEMBL2410774
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of BACE1 in human SH-SY5Y cells assessed as release of sAPPbeta after 17 hrs
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | SH-SY5Y |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
β-Secretase Inhibitors for the Treatment of Alzheimer's Disease and Down's Syndrome.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 4 | 8.80 | 10.51 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL2408786 | — | — | 1 | 10.51 |
| CHEMBL2408785 | — | — | 1 | 8.96 |
| CHEMBL2408787 | — | — | 1 | 8.96 |
| CHEMBL2408784 | — | — | 1 | 6.78 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL2408786 | — | IC50 | = | 0.031 | nM | 10.51 |
| CHEMBL2408785 | — | IC50 | = | 1.1 | nM | 8.96 |
| CHEMBL2408787 | — | IC50 | = | 1.1 | nM | 8.96 |
| CHEMBL2408784 | — | IC50 | = | 168.0 | nM | 6.78 |