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Assay Detail

CHEMBL2411100

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Binding
Binding affinity to human ERG expressed in CHO cells by IonWorks assay
17
Total Activities
17
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Organism Homo sapiens
Cell Type CHO
Confidence 9 — Direct single protein target
Curated By Autocuration

Publication

Structure and Property Based Design of Pyrazolo[1,5-a]pyrimidine Inhibitors of CK2 Kinase with Activity in Vivo.
Dowling JE, Alimzhanov M, Bao L, Block MH, Chuaqui C, Cooke EL, Denz CR, Hird A, Huang S, Larsen NA, Peng B, Pontz TW, Rivard-Costa C, Saeh JC, Thakur K, Ye Q, Zhang T, Lyne PD.
ACS Med Chem Lett (2013) 4 : 800 -805
PubMed 24900749 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 17 4.78 4.96

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL2409181 1 4.96
CHEMBL2409178 1 4.80
CHEMBL2409182 1 4.80
CHEMBL2409177 1 4.72
CHEMBL2409180 1 4.72
CHEMBL2409175 1 4.68
CHEMBL2409197 1 -
CHEMBL2409196 1 -
CHEMBL2409195 1 -
CHEMBL2409194 1 -
CHEMBL2409184 1 -
CHEMBL2409183 1 -
CHEMBL2407112 1 -
CHEMBL2409179 1 -
CHEMBL2409176 1 -
CHEMBL2409198 1 -
CHEMBL2409174 1 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL2409181 IC50 = 11000.0 nM 4.96
CHEMBL2409178 IC50 = 16000.0 nM 4.80
CHEMBL2409182 IC50 = 16000.0 nM 4.80
CHEMBL2409177 IC50 = 19000.0 nM 4.72
CHEMBL2409180 IC50 = 19000.0 nM 4.72
CHEMBL2409175 IC50 = 21000.0 nM 4.68
CHEMBL2409197 IC50 > 33000.0 nM -
CHEMBL2409196 IC50 > 33000.0 nM -
CHEMBL2409195 IC50 > 33000.0 nM -
CHEMBL2409194 IC50 - -
CHEMBL2409184 IC50 - -
CHEMBL2409183 IC50 - -
CHEMBL2407112 IC50 > 33000.0 nM -
CHEMBL2409179 IC50 - -
CHEMBL2409176 IC50 > 33000.0 nM -
CHEMBL2409198 IC50 > 33000.0 nM -
CHEMBL2409174 IC50 > 33000.0 nM -