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Assay Detail

CHEMBL2411275

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Binding
Inhibition of porcine kidney intestinal alkaline phosphatase using p-NPP as substrate treated 10 mins before substrate addition measured after 30 mins by spectrophotometric assay
21
Total Activities
21
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Organism Sus scrofa
Confidence 0 — Uncurated / Unknown
Curated By Autocuration

Target

Unchecked (CHEMBL612545)
Type UNCHECKED

Publication

Identification of novel chromone based sulfonamides as highly potent and selective inhibitors of alkaline phosphatases.
al-Rashida M, Raza R, Abbas G, Shah MS, Kostakis GE, Lecka J, Sévigny J, Muddassar M, Papatriantafyllopoulou C, Iqbal J.
Eur J Med Chem (2013) 66 : 438 -449
PubMed 23831808 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
Ki 21 4.80 7.68

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL2408701 1 7.68
CHEMBL2408705 1 7.10
CHEMBL2408700 1 5.55
CHEMBL1814391 1 4.96
CHEMBL2408702 1 4.93
CHEMBL2408703 1 4.75
CHEMBL1814397 1 4.70
CHEMBL1814400 1 4.70
CHEMBL2408699 1 4.67
CHEMBL2408560 1 4.67
CHEMBL2408704 1 4.50
CHEMBL2408698 1 4.45
CHEMBL1814396 1 4.38
CHEMBL1814393 1 4.35
CHEMBL1814398 1 4.29
CHEMBL2408697 1 4.28
CHEMBL1814394 1 4.26
CHEMBL1814399 1 4.17
CHEMBL1814392 1 4.17
CHEMBL1814395 1 4.16
CHEMBL2408706 1 4.13

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL2408701 Ki = 21.0 nM 7.68
CHEMBL2408705 Ki = 79.0 nM 7.10
CHEMBL2408700 Ki = 2800.0 nM 5.55
CHEMBL1814391 Ki = 10900.0 nM 4.96
CHEMBL2408702 Ki = 11700.0 nM 4.93
CHEMBL2408703 Ki = 18000.0 nM 4.75
CHEMBL1814397 Ki = 19900.0 nM 4.70
CHEMBL1814400 Ki = 20100.0 nM 4.70
CHEMBL2408699 Ki = 21300.0 nM 4.67
CHEMBL2408560 Ki = 21200.0 nM 4.67
CHEMBL2408704 Ki = 31800.0 nM 4.50
CHEMBL2408698 Ki = 35400.0 nM 4.45
CHEMBL1814396 Ki = 41700.0 nM 4.38
CHEMBL1814393 Ki = 44600.0 nM 4.35
CHEMBL1814398 Ki = 51300.0 nM 4.29
CHEMBL2408697 Ki = 52500.0 nM 4.28
CHEMBL1814394 Ki = 55300.0 nM 4.26
CHEMBL1814399 Ki = 67900.0 nM 4.17
CHEMBL1814392 Ki = 66800.0 nM 4.17
CHEMBL1814395 Ki = 68800.0 nM 4.16
CHEMBL2408706 Ki = 73600.0 nM 4.13