Assay Detail
Functional
CHEMBL2411333
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Cytotoxicity against human A549 cells after 72 hrs by sulforhodamine B assay
8
Total Activities
8
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | A549 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Naphthalimides exhibit in vitro antiproliferative and antiangiogenic activities by inhibiting both topoisomerase II (topo II) and receptor tyrosine kinases (RTKs).
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 8 | 4.83 | 5.50 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL428676 | AMONAFIDE | 3.0 | 1 | 5.50 |
| CHEMBL598852 | — | — | 1 | 5.11 |
| CHEMBL2407519 | — | — | 1 | 5.01 |
| CHEMBL598022 | — | — | 1 | 4.72 |
| CHEMBL2407518 | — | — | 1 | 4.67 |
| CHEMBL2407516 | — | — | 1 | 4.61 |
| CHEMBL2407635 | — | — | 1 | 4.50 |
| CHEMBL2407517 | — | — | 1 | 4.50 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL428676 | AMONAFIDE | IC50 | = | 3200.0 | nM | 5.50 |
| CHEMBL598852 | — | IC50 | = | 7800.0 | nM | 5.11 |
| CHEMBL2407519 | — | IC50 | = | 9800.0 | nM | 5.01 |
| CHEMBL598022 | — | IC50 | = | 19100.0 | nM | 4.72 |
| CHEMBL2407518 | — | IC50 | = | 21400.0 | nM | 4.67 |
| CHEMBL2407516 | — | IC50 | = | 24500.0 | nM | 4.61 |
| CHEMBL2407635 | — | IC50 | = | 31300.0 | nM | 4.50 |
| CHEMBL2407517 | — | IC50 | = | 31400.0 | nM | 4.50 |