Assay Detail
Binding
CHEMBL2411652
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Activation of GIRK1/2 (unknown origin) by thallium flux assay
2
Total Activities
2
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 7 — Homologous single protein target |
| Curated By | Autocuration |
Publication
Discovery of 'molecular switches' within a GIRK activator scaffold that afford selective GIRK inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 2 | 6.33 | 6.80 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL2409106 | — | — | 1 | 6.80 |
| CHEMBL86962 | — | — | 1 | 5.85 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL2409106 | — | EC50 | = | 160.0 | nM | 6.80 |
| CHEMBL86962 | — | EC50 | = | 1400.0 | nM | 5.85 |