Assay Detail
Binding
CHEMBL2411985
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of 3'-processing activity of HIV1 integrase using 32P-5'-TGTGGAAAATCTCTAGCAGT-3' and 5'-ACTGCTAGAGATTTTCCACA-3' as substrate after 1 hr by ELISA
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Human immunodeficiency virus 1 |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Human immunodeficiency virus type 1 integrase (CHEMBL3471) ↗| Type | SINGLE PROTEIN |
| Organism | Human immunodeficiency virus 1 |
Publication
4-Substituted 2-Hydroxyisoquinoline-1,3(2H,4H)-diones as a Novel Class of HIV-1 Integrase Inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 4 | 6.18 | 7.22 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL2407287 | — | — | 1 | 7.22 |
| CHEMBL254316 | RALTEGRAVIR | 4.0 | 1 | 6.05 |
| CHEMBL2407277 | — | — | 1 | 5.80 |
| CHEMBL2407284 | — | — | 1 | 5.63 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL2407287 | — | IC50 | = | 60.0 | nM | 7.22 |
| CHEMBL254316 | RALTEGRAVIR | IC50 | = | 900.0 | nM | 6.05 |
| CHEMBL2407277 | — | IC50 | = | 1580.0 | nM | 5.80 |
| CHEMBL2407284 | — | IC50 | = | 2350.0 | nM | 5.63 |