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Assay Detail

CHEMBL2412271

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Functional
Cytotoxicity against human A549 cells after 48 hrs by MTT assay
8
Total Activities
8
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Functional
Organism Homo sapiens
Cell Type A549
Confidence 1 — Organism
Curated By Autocuration

Target

A549 (CHEMBL392)
Type CELL-LINE
Organism Homo sapiens

Publication

Cytotoxic indole alkaloids from Tabernaemontana divaricata.
Bao MF, Yan JM, Cheng GG, Li XY, Liu YP, Li Y, Cai XH, Luo XD.
J Nat Prod (2013) 76 : 1406 -1412
PubMed 23944995 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 8 5.11 6.68

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL506768 CONOPHYLLINE 1 6.68
CHEMBL2409162 1 5.45
CHEMBL2409167 1 5.03
CHEMBL2409161 CONOFOLINE 1 4.99
CHEMBL2409166 1 4.83
CHEMBL2409164 1 4.78
CHEMBL2409165 1 4.54
CHEMBL2409163 1 4.54

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL506768 CONOPHYLLINE IC50 = 210.0 nM 6.68
CHEMBL2409162 IC50 = 3520.0 nM 5.45
CHEMBL2409167 IC50 = 9400.0 nM 5.03
CHEMBL2409161 CONOFOLINE IC50 = 10350.0 nM 4.99
CHEMBL2409166 IC50 = 14750.0 nM 4.83
CHEMBL2409164 IC50 = 16510.0 nM 4.78
CHEMBL2409165 IC50 = 28530.0 nM 4.54
CHEMBL2409163 IC50 = 28530.0 nM 4.54