Assay Detail
Functional
CHEMBL2412367
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Cytotoxicity against human MOLT4 cells after 72 hrs by MTT assay
8
Total Activities
8
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | MOLT-4 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Semisynthesis, cytotoxic activity, and oral availability of new lipophilic 9-substituted camptothecin derivatives.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 8 | 8.45 | 10.40 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL65 | CAMPTOTHECIN | -1.0 | 1 | 10.40 |
| CHEMBL2408025 | — | — | 1 | 7.85 |
| CHEMBL2408021 | — | — | 1 | 7.82 |
| CHEMBL84 | TOPOTECAN | 4.0 | 1 | 7.72 |
| CHEMBL2408024 | — | — | 1 | - |
| CHEMBL2408023 | — | — | 1 | - |
| CHEMBL2408022 | — | — | 1 | - |
| CHEMBL2408020 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL65 | CAMPTOTHECIN | IC50 | = | 0.04 | nM | 10.40 |
| CHEMBL2408025 | — | IC50 | = | 14.0 | nM | 7.85 |
| CHEMBL2408021 | — | IC50 | = | 15.0 | nM | 7.82 |
| CHEMBL84 | TOPOTECAN | IC50 | = | 19.0 | nM | 7.72 |
| CHEMBL2408024 | — | IC50 | - | — | - | |
| CHEMBL2408023 | — | IC50 | - | — | - | |
| CHEMBL2408022 | — | IC50 | - | — | - | |
| CHEMBL2408020 | — | IC50 | - | — | - |