Assay Detail
Functional
CHEMBL2412684
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Cytotoxicity against human PC3 cells after 48 hrs by sulforhodamine B assay
8
Total Activities
8
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | PC-3 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Synthesis and evaluation of diaryl sulfides and diaryl selenide compounds for antitubulin and cytotoxic activity.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 8 | 6.03 | 7.10 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL2409553 | — | — | 1 | 7.10 |
| CHEMBL2409551 | — | — | 1 | 6.70 |
| CHEMBL2409552 | — | — | 1 | 6.28 |
| CHEMBL53463 | DOXORUBICIN | 4.0 | 1 | 6.20 |
| CHEMBL67 | COMBRETASTATIN A4 | -1.0 | 1 | 6.00 |
| CHEMBL2409555 | — | — | 1 | 5.70 |
| CHEMBL2409554 | — | — | 1 | 5.17 |
| CHEMBL1978637 | — | — | 1 | 5.06 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL2409553 | — | IC50 | = | 80.0 | nM | 7.10 |
| CHEMBL2409551 | — | IC50 | = | 200.0 | nM | 6.70 |
| CHEMBL2409552 | — | IC50 | = | 530.0 | nM | 6.28 |
| CHEMBL53463 | DOXORUBICIN | IC50 | = | 630.0 | nM | 6.20 |
| CHEMBL67 | COMBRETASTATIN A4 | IC50 | = | 1000.0 | nM | 6.00 |
| CHEMBL2409555 | — | IC50 | = | 1990.0 | nM | 5.70 |
| CHEMBL2409554 | — | IC50 | = | 6750.0 | nM | 5.17 |
| CHEMBL1978637 | — | IC50 | = | 8800.0 | nM | 5.06 |