Assay Detail
Binding
CHEMBL2415166
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Inhibition of Pseudomonas aeruginosa PqsD using ACoA/beta-ketodecanoic acid as substrate assessed as HHQ formation incubated for 30 mins prior to ACoA addition followed by 10 mins after treated with beta-ketodecanoic acid measured for 40 mins
8
Total Activities
8
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Pseudomonas aeruginosa |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
Structure optimization of 2-benzamidobenzoic acids as PqsD inhibitors for Pseudomonas aeruginosa infections and elucidation of binding mode by SPR, STD NMR, and molecular docking.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 8 | 5.45 | 5.96 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL509952 | — | — | 1 | 5.96 |
| CHEMBL2413672 | — | — | 1 | 5.96 |
| CHEMBL2413674 | — | — | 1 | 5.80 |
| CHEMBL2413675 | — | — | 1 | 5.70 |
| CHEMBL2413697 | — | — | 1 | 5.38 |
| CHEMBL2413690 | — | — | 1 | 5.16 |
| CHEMBL2413681 | — | — | 1 | 4.89 |
| CHEMBL460994 | — | — | 1 | 4.71 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL509952 | — | IC50 | = | 1100.0 | nM | 5.96 |
| CHEMBL2413672 | — | IC50 | = | 1100.0 | nM | 5.96 |
| CHEMBL2413674 | — | IC50 | = | 1600.0 | nM | 5.80 |
| CHEMBL2413675 | — | IC50 | = | 2000.0 | nM | 5.70 |
| CHEMBL2413697 | — | IC50 | = | 4200.0 | nM | 5.38 |
| CHEMBL2413690 | — | IC50 | = | 7000.0 | nM | 5.16 |
| CHEMBL2413681 | — | IC50 | = | 12900.0 | nM | 4.89 |
| CHEMBL460994 | — | IC50 | = | 19400.0 | nM | 4.71 |