Assay Detail
Functional
CHEMBL2415230
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Cytotoxicity against human HT-29 cells assessed as growth inhibition after 72 hrs by MTS assay
23
Total Activities
23
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | HT-29 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Anticancer activity and SAR studies of substituted 1,4-naphthoquinones.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 23 | 5.15 | 5.98 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL2414138 | — | — | 1 | 5.98 |
| CHEMBL2414136 | — | — | 1 | 5.72 |
| CHEMBL2414137 | — | — | 1 | 5.71 |
| CHEMBL2414133 | — | — | 1 | 5.68 |
| CHEMBL2414123 | — | — | 1 | 5.67 |
| CHEMBL2414132 | — | — | 1 | 5.66 |
| CHEMBL295316 | PLUMBAGIN | 1.0 | 1 | 5.38 |
| CHEMBL2414129 | — | — | 1 | 5.26 |
| CHEMBL2414128 | — | — | 1 | 5.16 |
| CHEMBL43612 | JUGLONE | — | 1 | 5.11 |
| CHEMBL590 | MENADIONE | 4.0 | 1 | 5.01 |
| CHEMBL2414134 | — | — | 1 | 5.01 |
| CHEMBL2414127 | — | — | 1 | 5.00 |
| CHEMBL1631460 | — | — | 1 | 4.90 |
| CHEMBL55934 | NAPHTHOQUINONE | — | 1 | 4.89 |
| CHEMBL2414121 | — | — | 1 | 4.80 |
| CHEMBL92659 | — | — | 1 | 4.76 |
| CHEMBL2414130 | — | — | 1 | 4.72 |
| CHEMBL2414126 | — | — | 1 | 4.61 |
| CHEMBL2414135 | — | — | 1 | 4.58 |
| CHEMBL84010 | — | — | 1 | 4.50 |
| CHEMBL2414131 | — | — | 1 | - |
| CHEMBL2414122 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL2414138 | — | IC50 | = | 1050.0 | nM | 5.98 |
| CHEMBL2414136 | — | IC50 | = | 1890.0 | nM | 5.72 |
| CHEMBL2414137 | — | IC50 | = | 1970.0 | nM | 5.71 |
| CHEMBL2414133 | — | IC50 | = | 2110.0 | nM | 5.68 |
| CHEMBL2414123 | — | IC50 | = | 2160.0 | nM | 5.67 |
| CHEMBL2414132 | — | IC50 | = | 2170.0 | nM | 5.66 |
| CHEMBL295316 | PLUMBAGIN | IC50 | = | 4190.0 | nM | 5.38 |
| CHEMBL2414129 | — | IC50 | = | 5510.0 | nM | 5.26 |
| CHEMBL2414128 | — | IC50 | = | 6880.0 | nM | 5.16 |
| CHEMBL43612 | JUGLONE | IC50 | = | 7710.0 | nM | 5.11 |
| CHEMBL590 | MENADIONE | IC50 | = | 9690.0 | nM | 5.01 |
| CHEMBL2414134 | — | IC50 | = | 9680.0 | nM | 5.01 |
| CHEMBL2414127 | — | IC50 | = | 10020.0 | nM | 5.00 |
| CHEMBL1631460 | — | IC50 | = | 12640.0 | nM | 4.90 |
| CHEMBL55934 | NAPHTHOQUINONE | IC50 | = | 12760.0 | nM | 4.89 |
| CHEMBL2414121 | — | IC50 | = | 15650.0 | nM | 4.80 |
| CHEMBL92659 | — | IC50 | = | 17500.0 | nM | 4.76 |
| CHEMBL2414130 | — | IC50 | = | 19000.0 | nM | 4.72 |
| CHEMBL2414126 | — | IC50 | = | 24620.0 | nM | 4.61 |
| CHEMBL2414135 | — | IC50 | = | 26600.0 | nM | 4.58 |
| CHEMBL84010 | — | IC50 | = | 31250.0 | nM | 4.50 |
| CHEMBL2414131 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL2414122 | — | IC50 | > | 100000.0 | nM | - |