Assay Detail
Functional
CHEMBL2415246
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Cytotoxicity against human MCF7 cells after 72 hrs by MTT assay
12
Total Activities
12
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | MCF7 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Synthesis, self-aggregation and biological properties of alkylphosphocholine and alkylphosphohomocholine derivatives of cetyltrimethylammonium bromide, cetylpyridinium bromide, benzalkonium bromide (C16) and benzethonium chloride.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 12 | 5.12 | 7.16 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL334255 | CETYLPYRIDINIUM BROMIDE | — | 1 | 7.16 |
| CHEMBL2414246 | — | — | 1 | 6.00 |
| CHEMBL5314343 | — | — | 1 | 5.89 |
| CHEMBL221753 | BENZETHONIUM CHLORIDE | 2.0 | 1 | 5.30 |
| CHEMBL2414250 | — | — | 1 | 5.09 |
| CHEMBL125 | MILTEFOSINE | 4.0 | 1 | 4.72 |
| CHEMBL2414247 | — | — | 1 | 4.34 |
| CHEMBL2414251 | — | — | 1 | 4.30 |
| CHEMBL2414249 | — | — | 1 | 4.24 |
| CHEMBL2414248 | — | — | 1 | 4.12 |
| CHEMBL2414253 | — | — | 1 | - |
| CHEMBL2414252 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL334255 | CETYLPYRIDINIUM BROMIDE | IC50 | = | 70.0 | nM | 7.16 |
| CHEMBL2414246 | — | IC50 | = | 1000.0 | nM | 6.00 |
| CHEMBL5314343 | — | IC50 | = | 1300.0 | nM | 5.89 |
| CHEMBL221753 | BENZETHONIUM CHLORIDE | IC50 | = | 5000.0 | nM | 5.30 |
| CHEMBL2414250 | — | IC50 | = | 8100.0 | nM | 5.09 |
| CHEMBL125 | MILTEFOSINE | IC50 | = | 18900.0 | nM | 4.72 |
| CHEMBL2414247 | — | IC50 | = | 45200.0 | nM | 4.34 |
| CHEMBL2414251 | — | IC50 | = | 50400.0 | nM | 4.30 |
| CHEMBL2414249 | — | IC50 | = | 57600.0 | nM | 4.24 |
| CHEMBL2414248 | — | IC50 | = | 76000.0 | nM | 4.12 |
| CHEMBL2414253 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL2414252 | — | IC50 | > | 100000.0 | nM | - |