Assay Detail
Binding
CHEMBL2415524
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Displacement of [3H]-mesulergine from human 5HT2C receptor after 60 mins by liquid scintillation counting
7
Total Activities
7
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Synthesis and pharmacological evaluation of new N-phenylpiperazine derivatives designed as homologues of the antipsychotic lead compound LASSBio-579.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 7 | 5.57 | 7.64 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL42 | CLOZAPINE | 4.0 | 1 | 7.64 |
| CHEMBL2414355 | — | — | 1 | 5.55 |
| CHEMBL2414356 | — | — | 1 | 5.29 |
| CHEMBL2414357 | — | — | 1 | 5.23 |
| CHEMBL2414358 | — | — | 1 | 5.11 |
| CHEMBL2414354 | — | — | 1 | 5.09 |
| CHEMBL597601 | — | — | 1 | 5.06 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL42 | CLOZAPINE | Ki | = | 23.0 | nM | 7.64 |
| CHEMBL2414355 | — | Ki | = | 2800.0 | nM | 5.55 |
| CHEMBL2414356 | — | Ki | = | 5100.0 | nM | 5.29 |
| CHEMBL2414357 | — | Ki | = | 5900.0 | nM | 5.23 |
| CHEMBL2414358 | — | Ki | = | 7800.0 | nM | 5.11 |
| CHEMBL2414354 | — | Ki | = | 8100.0 | nM | 5.09 |
| CHEMBL597601 | — | Ki | = | 8630.0 | nM | 5.06 |