Assay Detail
Binding
CHEMBL2415549
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of human PARP-1 assessed as synthesis of [3H]-ADP-ribose polymers from [3H]-NAD+ by scintillation proximity assay
12
Total Activities
12
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
One-pot tandem Hurtley-retro-Claisen-cyclisation reactions in the synthesis of 3-substituted analogues of 5-aminoisoquinolin-1-one (5-AIQ), a water-soluble inhibitor of PARPs.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 12 | 6.04 | 6.64 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL2414048 | — | — | 1 | 6.64 |
| CHEMBL2414049 | — | — | 1 | 6.50 |
| CHEMBL2414042 | — | — | 1 | 6.48 |
| CHEMBL2414051 | — | — | 1 | 6.31 |
| CHEMBL2414046 | — | — | 1 | 6.24 |
| CHEMBL2414044 | — | — | 1 | 6.06 |
| CHEMBL2414045 | — | — | 1 | 6.05 |
| CHEMBL2414043 | — | — | 1 | 5.97 |
| CHEMBL2414052 | — | — | 1 | 5.93 |
| CHEMBL446240 | — | — | 1 | 5.80 |
| CHEMBL2414050 | — | — | 1 | 5.29 |
| CHEMBL2414047 | — | — | 1 | 5.25 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL2414048 | — | IC50 | = | 230.0 | nM | 6.64 |
| CHEMBL2414049 | — | IC50 | = | 320.0 | nM | 6.50 |
| CHEMBL2414042 | — | IC50 | = | 330.0 | nM | 6.48 |
| CHEMBL2414051 | — | IC50 | = | 490.0 | nM | 6.31 |
| CHEMBL2414046 | — | IC50 | = | 570.0 | nM | 6.24 |
| CHEMBL2414044 | — | IC50 | = | 880.0 | nM | 6.06 |
| CHEMBL2414045 | — | IC50 | = | 900.0 | nM | 6.05 |
| CHEMBL2414043 | — | IC50 | = | 1070.0 | nM | 5.97 |
| CHEMBL2414052 | — | IC50 | = | 1170.0 | nM | 5.93 |
| CHEMBL446240 | — | IC50 | = | 1600.0 | nM | 5.80 |
| CHEMBL2414050 | — | IC50 | = | 5140.0 | nM | 5.29 |
| CHEMBL2414047 | — | IC50 | = | 5610.0 | nM | 5.25 |