Assay Detail
Binding
CHEMBL2415771
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of PI3Kdelta (unknown origin) assessed as formation of PIP3 by competitive fluorescence polarization assay
16
Total Activities
16
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform (CHEMBL3130) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Identification of GNE-293, a potent and selective PI3Kδ inhibitor: navigating in vitro genotoxicity while improving potency and selectivity.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 16 | 8.91 | 9.64 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL2414299 | — | — | 1 | 9.64 |
| CHEMBL2414301 | — | — | 1 | 9.44 |
| CHEMBL2216902 | — | — | 1 | 9.33 |
| CHEMBL2216903 | — | — | 1 | 9.24 |
| CHEMBL2414297 | — | — | 1 | 9.23 |
| CHEMBL2414294 | — | — | 1 | 9.10 |
| CHEMBL2414300 | — | — | 1 | 9.06 |
| CHEMBL2414298 | — | — | 1 | 9.05 |
| CHEMBL2414238 | — | — | 1 | 8.96 |
| CHEMBL2171939 | — | — | 1 | 8.74 |
| CHEMBL2171952 | — | — | 1 | 8.70 |
| CHEMBL2171944 | — | — | 1 | 8.70 |
| CHEMBL2414239 | — | — | 1 | 8.64 |
| CHEMBL2414296 | — | — | 1 | 8.51 |
| CHEMBL2165501 | — | — | 1 | 8.26 |
| CHEMBL2414295 | — | — | 1 | 7.90 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL2414299 | — | Ki | = | 0.23 | nM | 9.64 |
| CHEMBL2414301 | — | Ki | = | 0.36 | nM | 9.44 |
| CHEMBL2216902 | — | Ki | = | 0.47 | nM | 9.33 |
| CHEMBL2216903 | — | Ki | = | 0.58 | nM | 9.24 |
| CHEMBL2414297 | — | Ki | = | 0.59 | nM | 9.23 |
| CHEMBL2414294 | — | Ki | = | 0.8 | nM | 9.10 |
| CHEMBL2414300 | — | Ki | = | 0.88 | nM | 9.06 |
| CHEMBL2414298 | — | Ki | = | 0.9 | nM | 9.05 |
| CHEMBL2414238 | — | Ki | = | 1.1 | nM | 8.96 |
| CHEMBL2171939 | — | Ki | = | 1.8 | nM | 8.74 |
| CHEMBL2171952 | — | Ki | = | 2.0 | nM | 8.70 |
| CHEMBL2171944 | — | Ki | = | 2.0 | nM | 8.70 |
| CHEMBL2414239 | — | Ki | = | 2.3 | nM | 8.64 |
| CHEMBL2414296 | — | Ki | = | 3.1 | nM | 8.51 |
| CHEMBL2165501 | — | Ki | = | 5.5 | nM | 8.26 |
| CHEMBL2414295 | — | Ki | = | 12.7 | nM | 7.90 |