Assay Detail
Binding
CHEMBL2415774
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Inhibition of PDE6 (unknown origin)
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 5 — Multiple protein complex / RNA |
| Curated By | Autocuration |
Publication
Exploration of the 5-bromopyrimidin-4(3H)-ones as potent inhibitors of PDE5.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 3 | 7.53 | 8.66 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL2414311 | — | — | 1 | 8.66 |
| CHEMBL2180942 | — | — | 1 | 8.13 |
| CHEMBL2414316 | — | — | 1 | 5.80 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL2414311 | — | IC50 | = | 2.2 | nM | 8.66 |
| CHEMBL2180942 | — | IC50 | = | 7.4 | nM | 8.13 |
| CHEMBL2414316 | — | IC50 | = | 1600.0 | nM | 5.80 |