Assay Detail
Binding
CHEMBL2415776
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of PDE5 (unknown origin)
18
Total Activities
18
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
cGMP-specific 3',5'-cyclic phosphodiesterase (CHEMBL1827) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Exploration of the 5-bromopyrimidin-4(3H)-ones as potent inhibitors of PDE5.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 18 | 7.82 | 8.77 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL2414316 | — | — | 1 | 8.77 |
| CHEMBL2414311 | — | — | 1 | 8.55 |
| CHEMBL2414317 | — | — | 1 | 8.40 |
| CHEMBL2414312 | — | — | 1 | 8.35 |
| CHEMBL2414308 | — | — | 1 | 8.21 |
| CHEMBL2414315 | — | — | 1 | 8.06 |
| CHEMBL2414313 | — | — | 1 | 8.02 |
| CHEMBL2414303 | — | — | 1 | 7.99 |
| CHEMBL2414310 | — | — | 1 | 7.96 |
| CHEMBL2414319 | — | — | 1 | 7.76 |
| CHEMBL2414314 | — | — | 1 | 7.74 |
| CHEMBL2414318 | — | — | 1 | 7.67 |
| CHEMBL2414307 | — | — | 1 | 7.59 |
| CHEMBL2414309 | — | — | 1 | 7.53 |
| CHEMBL2414302 | — | — | 1 | 7.32 |
| CHEMBL2414305 | — | — | 1 | 7.13 |
| CHEMBL2414304 | — | — | 1 | 7.11 |
| CHEMBL2414306 | — | — | 1 | 6.57 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL2414316 | — | IC50 | = | 1.7 | nM | 8.77 |
| CHEMBL2414311 | — | IC50 | = | 2.8 | nM | 8.55 |
| CHEMBL2414317 | — | IC50 | = | 4.0 | nM | 8.40 |
| CHEMBL2414312 | — | IC50 | = | 4.5 | nM | 8.35 |
| CHEMBL2414308 | — | IC50 | = | 6.2 | nM | 8.21 |
| CHEMBL2414315 | — | IC50 | = | 8.8 | nM | 8.06 |
| CHEMBL2414313 | — | IC50 | = | 9.6 | nM | 8.02 |
| CHEMBL2414303 | — | IC50 | = | 10.2 | nM | 7.99 |
| CHEMBL2414310 | — | IC50 | = | 11.1 | nM | 7.96 |
| CHEMBL2414319 | — | IC50 | = | 17.4 | nM | 7.76 |
| CHEMBL2414314 | — | IC50 | = | 18.2 | nM | 7.74 |
| CHEMBL2414318 | — | IC50 | = | 21.3 | nM | 7.67 |
| CHEMBL2414307 | — | IC50 | = | 25.5 | nM | 7.59 |
| CHEMBL2414309 | — | IC50 | = | 29.3 | nM | 7.53 |
| CHEMBL2414302 | — | IC50 | = | 48.0 | nM | 7.32 |
| CHEMBL2414305 | — | IC50 | = | 74.0 | nM | 7.13 |
| CHEMBL2414304 | — | IC50 | = | 77.0 | nM | 7.11 |
| CHEMBL2414306 | — | IC50 | = | 272.0 | nM | 6.57 |