Assay Detail

CHEMBL2420997

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Functional

Cytotoxicity against human W1L2 cells

ChEMBL ↗

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Target

WIL2 (CHEMBL612809) ↗

Open DB target context

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Primary target WIL2

CHEMBL612809

Anchored from Assay target.

Protein identity WIL2

Disease frame Disease evidence pending

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Review focus Open DB context pending

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Total Activities

Compounds Tested

Activity Types

Assay Parameters

Assay Information

Assay Type	Functional
Organism	Homo sapiens
Cell Type	WIL2
Confidence	1 — Organism
Curated By	Autocuration

Target

WIL2 (CHEMBL612809) ↗

Type	CELL-LINE
Organism	Homo sapiens

Publication

Medicinal chemistry of nicotinamide phosphoribosyltransferase (NAMPT) inhibitors.

Galli U, Travelli C, Massarotti A, Fakhfouri G, Rahimian R, Tron GC, Genazzani AA.
J Med Chem (2013) 56 : 6279 -6296
PubMed 23679915 · DOI

Activity Statistics

Type	Count	Avg pChEMBL	Best pChEMBL
EC50	2	8.93	9.31

Compounds Tested

Compound	Name	Phase	Activities	Best pChEMBL
CHEMBL2417796	—	—	1	9.31
CHEMBL123446	—	—	1	8.55

Activity Data

Compound	Name	Type	Rel.	Value	Units	pChEMBL
CHEMBL2417796	—	EC50	=	0.49	nM	9.31
CHEMBL123446	—	EC50	=	2.8	nM	8.55