Assay Detail
Functional
CHEMBL2421229
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Gametocytocidal activity against synchronous stage 4 to 5 of transgenic Plasmodium falciparum NF54 gametocyte harboring pfs16 promoter assessed as parasite viability after 72 hrs by MitoTracker Red CMXRos-based assay
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Plasmodium falciparum |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Novel conjugated quinoline-indoles compromise Plasmodium falciparum mitochondrial function and show promising antimalarial activity.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 5 | 5.86 | 8.10 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL361497 | ARTESUNATE | 4.0 | 1 | 8.10 |
| CHEMBL2419450 | — | — | 1 | 5.85 |
| CHEMBL2419641 | — | — | 1 | 5.72 |
| CHEMBL2419642 | — | — | 1 | 5.40 |
| CHEMBL76 | CHLOROQUINE | 4.0 | 1 | 4.22 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL361497 | ARTESUNATE | IC50 | = | 8.0 | nM | 8.10 |
| CHEMBL2419450 | — | IC50 | = | 1400.0 | nM | 5.85 |
| CHEMBL2419641 | — | IC50 | = | 1900.0 | nM | 5.72 |
| CHEMBL2419642 | — | IC50 | = | 4000.0 | nM | 5.40 |
| CHEMBL76 | CHLOROQUINE | IC50 | = | 60000.0 | nM | 4.22 |