Assay Detail
Functional
CHEMBL2421230
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Gametocytocidal activity against synchronous stage 1 to 3 of transgenic Plasmodium falciparum NF54 gametocyte harboring pfs16 promoter assessed as parasite viability after 72 hrs by luciferase reporter gene assay
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Plasmodium falciparum |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Novel conjugated quinoline-indoles compromise Plasmodium falciparum mitochondrial function and show promising antimalarial activity.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 5 | 6.80 | 7.72 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL361497 | ARTESUNATE | 4.0 | 1 | 7.72 |
| CHEMBL76 | CHLOROQUINE | 4.0 | 1 | 6.89 |
| CHEMBL2419642 | — | — | 1 | 6.52 |
| CHEMBL2419641 | — | — | 1 | 6.46 |
| CHEMBL2419450 | — | — | 1 | 6.43 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL361497 | ARTESUNATE | IC50 | = | 19.0 | nM | 7.72 |
| CHEMBL76 | CHLOROQUINE | IC50 | = | 130.0 | nM | 6.89 |
| CHEMBL2419642 | — | IC50 | = | 300.0 | nM | 6.52 |
| CHEMBL2419641 | — | IC50 | = | 350.0 | nM | 6.46 |
| CHEMBL2419450 | — | IC50 | = | 370.0 | nM | 6.43 |