Assay Detail
Functional
CHEMBL2421412
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Antimalarial activity against trophozoite stage of Plasmodium falciparum 3D7 infected in RBC assessed as growth inhibition after 5 hrs by SYBR Green-I fluorescence assay
6
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Plasmodium falciparum |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Novel conjugated quinoline-indoles compromise Plasmodium falciparum mitochondrial function and show promising antimalarial activity.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 6 | 7.23 | 9.40 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL129788 | — | — | 1 | 9.40 |
| CHEMBL76 | CHLOROQUINE | 4.0 | 1 | 7.52 |
| CHEMBL405110 | METHYLENE BLUE ANHYDROUS | 4.0 | 1 | 7.52 |
| CHEMBL2419639 | — | — | 1 | 6.77 |
| CHEMBL2419641 | — | — | 1 | 6.14 |
| CHEMBL2419642 | — | — | 1 | 6.00 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL129788 | — | IC50 | = | 0.4 | nM | 9.40 |
| CHEMBL76 | CHLOROQUINE | IC50 | = | 30.0 | nM | 7.52 |
| CHEMBL405110 | METHYLENE BLUE ANHYDROUS | IC50 | = | 30.0 | nM | 7.52 |
| CHEMBL2419639 | — | IC50 | = | 170.0 | nM | 6.77 |
| CHEMBL2419641 | — | IC50 | = | 730.0 | nM | 6.14 |
| CHEMBL2419642 | — | IC50 | = | 1000.0 | nM | 6.00 |