Assay Detail
Functional
CHEMBL2421415
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Antimalarial activity against Plasmodium falciparum K1 infected in RBC assessed as growth inhibition after 48 hrs by SYBR Green-I fluorescence assay
15
Total Activities
15
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Plasmodium falciparum |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Novel conjugated quinoline-indoles compromise Plasmodium falciparum mitochondrial function and show promising antimalarial activity.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 15 | 6.58 | 8.10 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL405110 | METHYLENE BLUE ANHYDROUS | 4.0 | 1 | 8.10 |
| CHEMBL2419642 | — | — | 1 | 6.92 |
| CHEMBL2419445 | — | — | 1 | 6.85 |
| CHEMBL2419448 | — | — | 1 | 6.72 |
| CHEMBL2419447 | — | — | 1 | 6.64 |
| CHEMBL2419641 | — | — | 1 | 6.64 |
| CHEMBL2419446 | — | — | 1 | 6.60 |
| CHEMBL76 | CHLOROQUINE | 4.0 | 1 | 6.52 |
| CHEMBL2419639 | — | — | 1 | 6.48 |
| CHEMBL2419450 | — | — | 1 | 6.41 |
| CHEMBL2419451 | — | — | 1 | 6.40 |
| CHEMBL2419449 | — | — | 1 | 6.36 |
| CHEMBL2419643 | — | — | 1 | 5.80 |
| CHEMBL2419640 | — | — | 1 | 5.66 |
| CHEMBL2113335 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL405110 | METHYLENE BLUE ANHYDROUS | IC50 | = | 8.0 | nM | 8.10 |
| CHEMBL2419642 | — | IC50 | = | 120.0 | nM | 6.92 |
| CHEMBL2419445 | — | IC50 | = | 140.0 | nM | 6.85 |
| CHEMBL2419448 | — | IC50 | = | 190.0 | nM | 6.72 |
| CHEMBL2419447 | — | IC50 | = | 230.0 | nM | 6.64 |
| CHEMBL2419641 | — | IC50 | = | 230.0 | nM | 6.64 |
| CHEMBL2419446 | — | IC50 | = | 250.0 | nM | 6.60 |
| CHEMBL76 | CHLOROQUINE | IC50 | = | 300.0 | nM | 6.52 |
| CHEMBL2419639 | — | IC50 | = | 330.0 | nM | 6.48 |
| CHEMBL2419450 | — | IC50 | = | 390.0 | nM | 6.41 |
| CHEMBL2419451 | — | IC50 | = | 400.0 | nM | 6.40 |
| CHEMBL2419449 | — | IC50 | = | 440.0 | nM | 6.36 |
| CHEMBL2419643 | — | IC50 | = | 1600.0 | nM | 5.80 |
| CHEMBL2419640 | — | IC50 | = | 2200.0 | nM | 5.66 |
| CHEMBL2113335 | — | IC50 | > | 5000.0 | nM | - |