Assay Detail
Binding
CHEMBL2421550
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of rat intestine maltase using maltose as substrate incubated for 10 mins prior to substrate addition measured after 40 mins by glucose oxidase colorimetric method
9
Total Activities
9
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Rattus norvegicus |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Quercitylcinnamates, a new series of antidiabetic bioconjugates possessing α-glucosidase inhibition and antioxidant.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 9 | 4.87 | 5.82 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL404271 | ACARBOSE | 4.0 | 1 | 5.82 |
| CHEMBL2418233 | — | — | 1 | 5.28 |
| CHEMBL2418237 | — | — | 1 | 4.68 |
| CHEMBL2418236 | — | — | 1 | 4.68 |
| CHEMBL145 | CAFFEIC ACID | 3.0 | 1 | 4.46 |
| CHEMBL2418235 | — | — | 1 | 4.29 |
| CHEMBL4296740 | BUTYLATED HYDROXYANISOLE | -1.0 | 1 | - |
| CHEMBL2418238 | — | — | 1 | - |
| CHEMBL2418234 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL404271 | ACARBOSE | IC50 | = | 1500.0 | nM | 5.82 |
| CHEMBL2418233 | — | IC50 | = | 5310.0 | nM | 5.28 |
| CHEMBL2418237 | — | IC50 | = | 20810.0 | nM | 4.68 |
| CHEMBL2418236 | — | IC50 | = | 21070.0 | nM | 4.68 |
| CHEMBL145 | CAFFEIC ACID | IC50 | = | 34690.0 | nM | 4.46 |
| CHEMBL2418235 | — | IC50 | = | 51930.0 | nM | 4.29 |
| CHEMBL4296740 | BUTYLATED HYDROXYANISOLE | IC50 | - | — | - | |
| CHEMBL2418238 | — | IC50 | = | 367150.0 | nM | - |
| CHEMBL2418234 | — | IC50 | = | 497480.0 | nM | - |